Objective: The purpose of this study was to subjectively evaluate the adequacy of the porcine model for training gynecologic oncology fellows.
Study Design: Following a defined surgical curriculum, fellow-attending pairs operated on female hogs. A predetermined dataset was collected for each procedure.
Results: Twenty pigs were operated on. The porcine model was determined to be a good model for laparoscopic lymphadenectomy (11), ureteroneocystostomy (7), repair of vascular injury (11), bowel anastamoses (21), distal pancreatectomy (5), nephrectomy (6), partial hepatectomy (5), diaphram stripping (5), and diaphragmatic resection (4). Two attendings and 1 fellow judged the porcine model to be fair (remaining 11 good) for ileocolonic urinary diversion, mainly due to significant differences in anatomy. Liver mobilization (5) and splenectomy (11) were determined to be fair or poor models by all participants due to the limited attachments in the pig.
Conclusion: The porcine model is adequate for teaching some ancillary gynecologic oncology surgical procedures and is inadequate for others.
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http://dx.doi.org/10.1016/j.ajog.2009.04.050 | DOI Listing |
Mol Med
December 2024
Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.
Vertebrates differ over 100,000-fold in responses to pro-inflammatory agonists such as bacterial lipopolysaccharide (LPS), complicating use of animal models to study human sepsis or inflammatory disorders. We compared transcriptomes of resting and LPS-exposed blood from six LPS-sensitive species (rabbit, pig, sheep, cow, chimpanzee, human) and four LPS-resilient species (mice, rats, baboon, rhesus), as well as plasma proteomes and lipidomes. Unexpectedly, at baseline, sensitive species already had enhanced expression of LPS-responsive genes relative to resilient species.
View Article and Find Full Text PDFIntensive Care Med Exp
December 2024
Faculty of Nursing and Health Sciences, Nord University, Bodø, Norway.
Background: Identifying spontaneous circulation during cardiopulmonary resuscitation (CPR) is challenging. Current methods, which involve intermittent and time-consuming pulse checks, necessitate pauses in chest compressions. This issue is problematic in both in-hospital cardiac arrest and out-of-hospital cardiac arrest situations, where resources for identifying circulation during CPR may be limited.
View Article and Find Full Text PDFSci Rep
December 2024
School of Mechanical and Electrical Engineering, Qiqihar University, Qiqihar, 161006, China.
A prediction model of the pig house environment based on Bayesian optimization (BO), squeeze and excitation block (SE), convolutional neural network (CNN) and gated recurrent unit (GRU) is proposed to improve the prediction accuracy and animal welfare and take control measures in advance. To ensure the optimal model configuration, the model uses a BO algorithm to fine-tune hyper-parameters, such as the number of GRUs, initial learning rate and L2 normal form regularization factor. The environmental data are fed into the SE-CNN block, which extracts the local features of the data through convolutional operations.
View Article and Find Full Text PDFSci Rep
December 2024
Pharmacology Research Group, Universidad del Valle, Colombia, Cali, 760043.
Vascularized composite allotransplantation (VCA) represents a clinical challenge for transplant therapy, as it involves different tissues with unique immunogenicity. Even when receiving immunosuppressive therapy, they are more vulnerable to severe hypoxia, microvascular damage, and ultimately the rejection or chronic graft dysfunction after transplantation. This study aimed to develop a surgical protocol for VCA of the ear in a porcine biomodel in the absence of immunosuppression, maintaining the in vitro co-culture of the allograft and assessing their relationship with allograft survival.
View Article and Find Full Text PDFVet Sci
December 2024
School of Agricultural and Veterinary Sciences, São Paulo State University (UNESP), Jaboticabal 14884-900, SP, Brazil.
Respiratory diseases, such as pleurisy and pneumonia, cause significant health and economic losses in pig production. This study evaluated 867 finishing pigs from a farm with a history of respiratory issues, using macroscopic lesion scoring (SPES and CVPC), histopathological analysis, qPCR diagnostics, and economic modeling. Severe pleurisy (scores 3 and 4) was observed in 42.
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