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[Brain tumors in patients with intractable epilepsy: a clinicopathologic study of 35 cases]. | LitMetric

[Brain tumors in patients with intractable epilepsy: a clinicopathologic study of 35 cases].

Zhonghua Bing Li Xue Za Zhi

Department of Pathology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.

Published: March 2009

AI Article Synopsis

  • The study examines the characteristics of brain tumors found in 35 patients who suffer from epilepsy that doesn't respond to medication, analyzing data from January 2005 to April 2008.
  • Results revealed that most participants had seizure onset around 14 years old, with tumors predominantly located in the temporal lobe and a high percentage showing abnormal MRI signals.
  • The findings indicate that these tumors are mainly benign and often consist of mixed neuronal-glial types, suggesting a potential common cause for their development.

Article Abstract

Objective: To study the clinicopathologic features of brain tumors occurring in patients with medically intractable epilepsy.

Methods: The clinical, radiologic and pathologic features of brain tumors occurring in 35 patients with intractable epilepsy encountered during the period from January, 2005 to April, 2008 in Xuanwu Hospital were retrospectively reviewed.

Results: The mean age of seizure onset and duration of disease were 14.3-year-old and 8.6 years, respectively. Abnormal signals were observed in 94.3% of cases (33/35) by magnetic resonance imaging. The histologic types of brain tumors included ganglioglioma (13/35, WHO grade I and 6/35, WHO grade II), dysembryoplastic neuroepithelial tumor (3/35, WHO grade I), pleomorphic xanthoastrocytoma (3/35, WHO grade II), diffuse astrocytoma (1/35, WHO grade II), oligoastrocytoma (1/35, WHO grade II), angiocentric glioma (1/35, WHO grade I) and meningioangiomatosis (1/35). The 6 remaining cases showed features seen in between glioneuronal hamartoma and mixed neuronal-glial tumor. Most of these tumors were located in the temporal lobe (27/35) and associated with focal cortical dysplasia. Immunohistochemical study showed a remarkable expression of CD34 in gangliogliomas.

Conclusions: Brain tumors in patients with medically intractable epilepsy are almost always benign and located in the temporal lobe. Most of them represent mixed neuronal-glial tumors and some show transitional features in-between glioneuronal hamartoma and mixed neuronal-glial neoplasm. The similar morphologic pattern and biological behavior of glioneuronal hamartoma and mixed neuronal-glial tumor may suggest a common pathogenetic mechanism.

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