Objectives: To evaluate the performance of cervical phosphorylated insulin-like growth factor binding protein-1 (phIGFBP-1) testing and cervical length measurement separately and in combination with physician's clinical judgment in prediction of preterm birth among patients with self-reported uterine contractions and intact membranes.

Design: We enrolled a total of 246 women between 22 and 34 weeks of gestation.

Methods: The initial evaluation included cervical length measurement using transvaginal ultrasonography. Short cervix was defined as <25 mm. A swab sample was obtained from the cervix for phIGFBP-1. Admission was used as a clinical marker of an increased risk of preterm delivery
Main Outcome Measures: Delivery
Results: The overall rate of spontaneous preterm delivery
Conclusion: The rapid phIGFBP-1-test has a high negative predictive value for preterm delivery, comparable to that of ultrasonographic cervical length measurement.

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http://dx.doi.org/10.1080/00016340903104281DOI Listing

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