AI Article Synopsis
- The text presents a new method for inhibiting the alphavbeta3 integrin, which is a protein that plays a role in various biological processes.
- This approach focuses on using specially designed compounds that achieve nanomolar (nM) potency, meaning they are very effective at low concentrations.
- Importantly, this method does not rely on the traditional arginine binding site for its effectiveness, suggesting a novel mechanism of action.
Article Abstract
A novel approach to inhibition of the alphavbeta3 integrin is described, which uses compounds designed to generate nM potency without using the arginine binding site.
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| http://dx.doi.org/10.1016/j.bmcl.2009.06.041 | DOI Listing |
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