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Discrete event simulation model of an acute stroke treatment process at a comprehensive stroke center: Determining the ideal improvement strategies for reducing treatment times.
J Neurol Sci
January 2025
Department of Industrial Engineering, Faculty of Engineering, Dalhousie University, Halifax, Canada; Division of Neurology, Department of Medicine, Dalhousie University, Halifax, Canada; Department of Community Health and Epidemiology, Faculty of Medicine, Dalhousie University, Halifax, Canada.
Background: Fast treatment is crucial for ischemic stroke patients; the probability of good patient outcomes increases with faster treatment. Treatment times can be improved by making changes to the treatment process. However, it is challenging to identify the benefits of changes prior to implementation.
View Article and Find Full Text PDFIntravenous thrombolysis in young adults with ischemic stroke: A cohort study from the international TRISP collaboration.
Eur Stroke J
December 2024
Department of Neurology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Background And Aims: Previous observational data indicate that young adults treated with intravenous thrombolysis (IVT) for acute ischemic stroke have more favorable outcomes and less complications when compared to older adults. Given the limited data on this topic, we aimed to provide more evidence on clinical outcomes and safety in such patients, using a large international thrombolysis registry.
Methods: In this prospective multicenter study, we used data from the Thrombolysis in Ischemic Stroke Patients (TRISP) registry from 1998 to 2020.
Outcome in acute ischemic stroke patients treated with intravenous thrombolysis - a retrospective and statistical analysis of five years' experience.
Rom J Morphol Embryol
November 2024
Department of Histology, University of Medicine and Pharmacy of Craiova, Romania;
This paper represents a retrospective study on 252 patients with acute ischemic stroke (AIS), who received thrombolytic therapy between 2019-2023, in the Department of Neurology at the Emergency County Hospital in Craiova, Romania. We aimed to evaluate treatment complications and short-term outcomes of patients with AIS, treated with intravenous (i.v.
View Article and Find Full Text PDFPotential Predictive Value of Platelet Distribution Width for Functional Outcome After Ischemic Stroke.
Mol Neurobiol
October 2024
Institute of Cerebrovascular Diseases Research and Department of Neurology, Xuanwu Hospital of Capital Medical University, 45 Changchun Street, Beijing, 100053, China.
Article Synopsis
- Complete blood cell count (CBC) testing, commonly used in clinical settings, has been linked to ischemic stroke outcomes, but the exact cause-and-effect relationships remain unclear.
- This study investigates the causal links between CBC indices, specifically focusing on platelet distribution width (PDW), and patient outcomes three months after ischemic stroke, using data from large genetic databases.
- The findings suggest that higher genetically determined PDW is associated with worse outcomes post-stroke, although it does not significantly improve predictive models for stroke outcomes and its connection to stroke prognosis may be indirect, potentially influenced by factors like serum glucose levels.
Clinicopathological Observations in Acute Stroke Patients Treated with Intravenous Thrombolysis.
J Clin Med
October 2024
Department of Neurology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
: Ischemic stroke is a leading cause of mortality worldwide, and intravenous thrombolysis, while improving functional outcomes, still leaves a significant mortality rate. This study aimed to investigate the clinical and pathological data of thrombolysed stroke patients who subsequently died and underwent autopsy, focusing on hemorrhagic transformation (HT). : Over a 10-year period, 1426 acute ischemic stroke patients received thrombolysis at our center, with an in-hospital mortality rate of 11.
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