Objective: To investigate current dietary intakes of arachidonic acid (AA), docosahexaenoic acid (DHA) in healthy children between 4-7 years of age using a 3-day food record.
Design: Cross-sectional study investigating dietary intakes using food records. Parents were instructed to document all food and drink consumed by their child for 3 consecutive days.
Subjects And Setting: Healthy children (n = 91), 4-7 years of age, living in central Alberta, Canada were volunteered by their parents to participate in the study. Seventy-eight children completed the study.
Results: AA and DHA intakes were 57 +/- 35 mg/day and 37 +/- 63 mg/day, ranged between 1.2-180 mg/day and 0-350 mg/day and varied day to day at 0-380 mg/day and 0-991 mg/d, respectively. DHA intake was
Conclusion: Canadian children, 4-7 years of age and not living near a marine environment, have relatively low dietary intakes of AA and DHA. Retinal and neuronal development continues throughout childhood, therefore it is conceivable that low intake of AA and DHA may have a negative impact.
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http://dx.doi.org/10.1080/07315724.2009.10719755 | DOI Listing |
Nutrients
January 2025
State Key Laboratory Incubation Base for Green Processing of Chemical Engineering, School of Chemistry and Chemical Engineering, Shihezi University, Shihezi 832003, China.
Objectives: Polysaccharides from are known to have several bioactive effects. Previous studies have found that low-molecular-weight polysaccharide (GP1) is degraded by and promotes the production of beneficial bacteria and metabolites, which improves immune disorder and intestinal injury, and then enhances the body's immune regulation ability. However, the immune regulation effect of GP1 on a healthy body has not been studied.
View Article and Find Full Text PDFPharmaceuticals (Basel)
January 2025
Health Sciences Postgraduate Program, São Francisco University-USF, Bragança Paulista 12916-900, SP, Brazil.
Background/objectives: This study investigates the metabolic profile of a single dose of etodolac in healthy volunteers, focusing on pharmacokinetics, clinical parameters, and metabolomic variations to identify biomarkers and pathways linked to drug response, efficacy, and safety.
Methods: Thirty-seven healthy volunteers, enrolled after rigorous health assessments, received a single dose of etodolac (Flancox 500 mg). Pharmacokinetic profiles were determined using tandem mass spectrometry analysis, and the metabolomic profiling was conducted using baseline samples (pre-dose) and samples at maximum drug concentration (post-dose) via liquid chromatography coupled with a quadrupole time-of-flight mass spectrometer.
Int J Mol Sci
January 2025
Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Provincial Key Laboratory of Agricultural & Rural Pollution Abatement and Environmental Safety, College of Natural Resources and Environment, South China Agricultural University, Guangzhou 510642, China.
Cadmium (Cd) pollution poses an important problem, but limited information is available about the toxicology effects of Cd on freshwater invertebrates. We investigated the accumulation, oxidative stress, microbial community changes, and transcriptomic alterations in apple snails ) under Cd stress. The snails were exposed to the 10 μg/L Cd solution for 16 days, followed by a 16-day elimination period.
View Article and Find Full Text PDFBiomolecules
January 2025
Department of Chemistry, Cleveland State University, Cleveland, OH 44115, USA.
Allergic rhinitis affects millions globally, causing significant discomfort and reducing the quality of life. This study investigates the metabolic alterations in murine mast cells (MC/9) under allergic rhinitis conditions induced by lipopolysaccharide (LPS) stimulation, employing UHPLC-QTOF-MS-based untargeted and targeted metabolomics. The analysis identified 44 significantly regulated metabolites, including histamine, leukotrienes, prostaglandins, thromboxanes, and ceramides.
View Article and Find Full Text PDFAnimals (Basel)
January 2025
Facultad de Ciencias Agropecuarias y Medioambiente, Universidad de La Frontera, Temuco 4780000, Chile.
Worldwide, there are reports indicating that sheep raised in insular systems spontaneously consume seaweed. In the southern hemisphere, there exists , a brown seaweed that possesses minerals and fatty acids that could improve some aspects of sheep production and meat quality, respectively. However, the consumption of this algae in lambs has been scarcely studied.
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