Transcriptional errors in human immunodeficiency virus type 1 generate targets for T-cell responses.

Clin Vaccine Immunol

Division of Experimental Medicine, Department of Medicine, UCSF, San Francisco, California 94110, USA.

Published: September 2009

We measured T-cell responses to human immunodeficiency virus type 1 (HIV-1) cryptic epitopes encoded by regions of the viral genome not normally translated into viral proteins. T-cell responses to cryptic epitopes and to regions normally spliced out of the HIV-1 viral proteins Rev and Tat were detected in HIV-1-infected subjects.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745002PMC
http://dx.doi.org/10.1128/CVI.00410-08DOI Listing

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