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Rapid Determination of Water-Soluble Vitamins in Human Serum by Ultrahigh-Performance Liquid Chromatography-Tandem Mass Spectrometry.
ACS Omega
January 2025
Clinical Nuclear Medicine Center, Imaging Clinical Medical Center, Institute of Nuclear Medicine, Institute of Clinical Mass Spectrometry Applied Research Center, Department of Nuclear Medicine, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China.
Water-soluble vitamins play essential roles in normal body functions and metabolic activities. However, few methods have simultaneously measured all nine water-soluble vitamins in biological matrices. In this study, we developed a sensitive and accurate method for the simultaneous measurement of thiamine (B1), riboflavin (B2), nicotinamide (B3), pantothenic acid (B5), 4-pyridoxic acid (B6), biotin (B7), 5-methyltetrahydrofolic acid (B9), ascorbic acid (VC), and methylmalonic acid (MMA) in human serum.
View Article and Find Full Text PDFMonitoring CO as a plant signaling molecule under heavy metal stress using carbon nanodots.
Dalton Trans
January 2025
Department of Chemistry, Visva-Bharati University, Santiniketan-731235, India.
Carbon monoxide (CO) is widely recognized as a significant environmental pollutant and is associated with numerous instances of accidental poisoning in humans. However, it also serves a pivotal role as a signaling molecule in plants, exhibiting functions analogous to those of other gaseous signaling molecules, including nitric oxide (NO) and hydrogen sulfide (HS). In plant physiology, CO is synthesized as an integral component of the defense mechanism against oxidative damage, particularly under abiotic stress conditions such as drought, salinity, and exposure to heavy metals.
View Article and Find Full Text PDFNanopore Detection of Small Molecules Based on Replacement and Complexation Chemical Interactions.
Small
January 2025
Department of Chemistry, University of Missouri, Columbia, MO, 65211, USA.
Small molecules play important roles in a variety of biological processes such as metabolism, cell signaling and enzyme regulation, and can serve as valuable biomarkers for human diseases. Moreover, they are essential to drug discovery and development, and are important targets for environmental monitoring and food safety. Due to the size incompatibility, small molecule transport is difficult to be monitored with a nanopore.
View Article and Find Full Text PDFChitinase-3-like-1: a multifaceted player in neuroinflammation and degenerative pathologies with therapeutic implications.
Mol Neurodegener
January 2025
Research Center for Neuroscience, Taipei Medical University, Taipei, Taiwan.
Chitinase-3-like-1 (CHI3L1) is an evolutionarily conserved protein involved in key biological processes, including tissue remodeling, angiogenesis, and neuroinflammation. It has emerged as a significant player in various neurodegenerative diseases and brain disorders. Elevated CHI3L1 levels have been observed in neurological conditions such as traumatic brain injury (TBI), Alzheimer's disease (AD), Parkinson's disease (PD), Amyotrophic lateral sclerosis (ALS), Creutzfeldt-Jakob disease (CJD), multiple sclerosis (MS), Neuromyelitis optica (NMO), HIV-associated dementia (HAD), Cerebral ischemic stroke (CIS), and brain tumors.
View Article and Find Full Text PDFSelf-perceived impact of COVID-19 and risk behaviors among adolescents: Results from the HBSC 2021/22 study in 21 European countries.
Addict Behav
December 2024
Department of Public Health and Pediatrics, University of Torino, Italy.
Aims: To investigate adolescents' perception of the impact of the COVID-19 pandemic on several aspects of their lives (mental health, well-being, family situation, peers, school, dieting, and physical activity) in relation to risk behaviors such as smoking, alcohol use, drunkenness, and cannabis use.
Methods: Data were used from the Health Behaviour in School-aged Children (HBSC) study conducted in 2021/2022, comprising 106,221 adolescents aged 11-15 (50.9% females) from 21 European countries.
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