[Lymphoma presenting with unusual combination of clinical features: a case report and literature review].

Objective: To describe a case of lymphoma presenting with multi-organ involvement, and to review similar cases reported in the English and Chinese literatures since 1994.

Methods: The clinical and pathological features of a patient admitted to our hospital on September 6, 2007 with lymphoma presenting with some unusual clinical symptoms including subcutaneous nodules, pleural effusion and orbital tumor were analyzed and related literatures were reviewed.

Results: The patient was a 60-year-old male. The primary manifestations were subcutaneous nodules. The reason for his hospitalization was pleural effusion. Orbital tumor was present. Computed tomography of the chest and the abdomen reveal systemic lymphadenopathy. Lymphoma was proved by pathological study.

Conclusions: Complicated clinical manifestations of lymphoma may have multi-system involvement. Lymphoma with extranodal presentations as the first sign may lead to misdiagnosis.