Objective: To prepare Compound PuHuang Granules and observe its clinical efficacy on cerebral infarction.
Methods: The Compound PuHuang Granules were prepared and the identification was performed by TLC. A total of 328 patients with cerebral infarction were randomly divided into two groups and observed. 197 cases in the trial group were administered with Compound PuHuang Granules for 2 weeks, and 131 cases in the control group were administered with NaoXueShuan Tablets for 2 weeks as well.
Results: The method of identification was proved to be specific and reproductive. The effective rates of the trial group and the control group on vertigo, hemiplegia, numbness of extremities were 88.71%, 82.46%, 84.38% and 61.11%, 62.07%, 66.67%, respectively, which showed significances between the two groups (P < 0.05). But the effective rates of two groups on language disorder showed no signifcance.
Conclusions: The Compound PuHuang Granules is feasible in preparation and it has obvious efficacy, therefore, it would be useful in the clinical applications.
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The changes of bioactive constituents were analyzed for Puhuang-Wulingzhi before and after compatibility and the antiplatelet and antithrombin activitives were evaluated in order to elucidate the scientific and reasonable of Puhuang-Wulingzhi compatibility. UPLC-QTOF-MA-Markerlynx, principal component analysis (PCA) and orthogonal partial least-squares discriminant analysis were used for data analysis and tracking changes of chemical composition during the decocting process. In vitro platelet aggregation induced by ADP, thrombin time(TT) and prothrombin time (PT) were investigated for Puhuang-Wulingzhi before and after compatibility.
View Article and Find Full Text PDFZhong Yao Cai
March 2009
Department of Pharmacy, Tenth People's Hospital, Tongji University, Shanghai 200072, China.
Objective: To prepare Compound PuHuang Granules and observe its clinical efficacy on cerebral infarction.
Methods: The Compound PuHuang Granules were prepared and the identification was performed by TLC. A total of 328 patients with cerebral infarction were randomly divided into two groups and observed.
Zhongguo Zhong Yao Za Zhi
February 1993
Chinese Medicinal Material Research Centre, Chinese University of Hongkong.
I.P. injection (5g crude drug/kg) of water extract of Puhuang (Typha orientalis) to S.
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