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Gold manno-glyconanoparticles: multivalent systems to block HIV-1 gp120 binding to the lectin DC-SIGN.
Chemistry
September 2009
Laboratory of GlycoNanotechnology, Biofunctional Nanomaterial Unit, CIC biomaGUNE and CIBER-BBN, Parque Tecnológico, San Sebastián, Spain.
The HIV envelope glycoprotein gp120 takes advantage of the high-mannose clusters on its surface to target the C-type lectin dendritic cell-specific intracellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) on dendritic cells. Mimicking the cluster presentation of oligomannosides on the virus surface is a strategy for designing carbohydrate-based antiviral agents. Bio-inspired by the cluster presentation of gp120, we have designed and prepared a small library of multivalent water-soluble gold glyconanoparticles (manno-GNPs) presenting truncated (oligo)mannosides of the high-mannose undecasaccharide Man(9)GlcNAc(2) and have tested them as inhibitors of DC-SIGN binding to gp120.
View Article and Find Full Text PDFMultivalent manno-glyconanoparticles inhibit DC-SIGN-mediated HIV-1 trans-infection of human T cells.
Chembiochem
July 2009
Laboratory of GlycoNanotechnology, CIC biomaGUNE/CIBER-BBN, P degrees Miramón 182, 20009 San Sebastián, Spain.
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