AI Article Synopsis
- The study explores injuries from stingray bites in Hormozgan province, highlighting intense pain and occasional redness, spasms, and seizures in three patients.
- Researchers estimated the lethal dose (LD(50)) of stingray venom (from Himantura gerrardi) in mice to be about 100 mg per kg using specialized dosing methods.
- In rat experiments, symptoms from venom included increased heart rate and notable changes in electrocardiogram (ECG) parameters such as T and Q values, along with PR and RR intervals.
Article Abstract
Stingrays are common inhabitants in the northern waters of the Persian Gulf and Oman Sea. In the present study, the clinical aspects of injuries induced in three patients bitten by stingrays in Hormozgan province waters were first examined. The LD(50) of crude venom extract obtained from the most common stingray in Hormozgan province (Himantura gerrardi) was then estimated by up-and-down dosing and double dose methods in mice. Third and finally, the cardiac symptoms induced by injection of the extract from the venomous spines were evaluated in rats. Intense pain was noticed in all human cases. Redness was observed in two cases, and spasm and seizure were each recorded in only one case. LD(50) of the venom extract in mice was about 100 mg kg(-1). The observed cardiac symptoms in rats included an increase in pulse rate and various changes in electrocardiogram (ECG) parameters such as T and Q values, and PR and RR intervals.
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| http://dx.doi.org/10.1016/j.toxicon.2009.06.023 | DOI Listing |
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