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Homelessness is a growing concern in the United States, especially among people who use drugs (PWUD). The degree of material hardship among this population may be linked to worse health outcomes. PWUD experiencing homelessness in urban areas are increasingly subjected to policies and social treatment, such as forced displacement, which may worsen material hardship.
View Article and Find Full Text PDFReactive Brownian Dynamics of Chemically Fueled Droplets: Roles of Attraction and Deactivation Modes.
J Phys Chem B
January 2025
Applied Theoretical Physics - Computational Physics, Physikalisches Institut, Albert-Ludwigs-Universität Freiburg, 79104 Freiburg, Germany.
The self-assembly of biological membraneless organelles can be mimicked by active droplets resulting from chemically fueled microphase separation. However, how the nonequilibrium, transient structure of these active droplets can be controlled through the physicochemical input parameters is not yet well understood. In our work, a chemically fueled two-state chemical reaction and subsequent droplet growth and decay are modeled with a reactive Brownian dynamics simulation in two spatial dimensions.
View Article and Find Full Text PDFAssessing immunotherapy response: going beyond RECIST by integrating early tumor growth kinetics.
Front Immunol
January 2025
Median Technologies, Imaging Lab, Valbonne, France.
Objective: Assess the contribution of early tumor growth dynamics modeling to predict clinical outcomes in non-small cell lung cancer patients receiving immunotherapy, alongside standard RECIST 1.1 criteria.
Methods: Our retrospective studies used data from 861 patients with advanced NSCLC enrolled in three randomized Phase III trials evaluating immunotherapy plus chemotherapy were analyzed.
Modeling lake conductivity in the contiguous United States using spatial indexing for big spatial data.
Spat Stat
March 2024
United States Environmental Protection Agency, 200 SW 35th St, Corvallis, OR, USA.
Conductivity is an important indicator of the health of aquatic ecosystems. We model large amounts of lake conductivity data collected as part of the United States Environmental Protection Agency's National Lakes Assessment using spatial indexing, a flexible and efficient approach to fitting spatial statistical models to big data sets. Spatial indexing is capable of accommodating various spatial covariance structures as well as features like random effects, geometric anisotropy, partition factors, and non-Euclidean topologies.
View Article and Find Full Text PDFBilateral alterations in sensorimotor function and altered sensory strategy in individuals with unilateral chronic ankle instability.
J Exerc Sci Fit
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Sports Medicine and Rehabilitation Center, Shanghai University of Sport, Shanghai, China.
Article Synopsis
- The study aimed to assess the sensorimotor function in patients with unilateral chronic ankle instability (CAI) and compare their abilities to healthy controls, focusing on sensory reweighting and vestibular modulation.
- Twenty individuals with unilateral CAI and twenty healthy participants underwent various tests to evaluate ankle proprioception, plantar sensation, balance, and motor control, using a mix of analyses to compare the groups.
- Results indicated that those with CAI had increased sensory thresholds for light touch and two-point discrimination bilaterally, moderate deficits in certain motor control measures, and showed postural instability in balance tests when compared to healthy controls.
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