The synthesis and SAR of a new series of potent and selective dopamine D(3) receptor antagonists is reported.
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| http://dx.doi.org/10.1016/j.bmcl.2009.06.043 | DOI Listing |
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Function of orexin-1 receptor signaling in the olfactory tubercle in odor-guided attraction and aversion.
Commun Biol
December 2024
Department of Physiology, Kochi Medical School, Kochi University, Kochi, Japan.
While olfactory behaviors are influenced by neuromodulatory signals, the underlying mechanism remains unknown. The olfactory tubercle (OT), a component of the olfactory cortex and ventral striatum, consists of anteromedial (am) and lateral (l) domains regulating odor-guided attractive and aversive behaviors, respectively, in which the amOT highly expresses various receptors for feeding-regulated neuromodulators. Here we show functions of appetite-stimulating orexin-1 receptor (OxR1) signaling in the amOT.
View Article and Find Full Text PDFA multimodal neuroimaging study of youth at risk for substance use disorders: Functional magnetic resonance imaging and [F]fallypride positron emission tomography.
Alcohol Clin Exp Res (Hoboken)
December 2024
Integrated Program in Neuroscience, McGill University, Montreal, Quebec, Canada.
Background: Adolescent alcohol use is the norm, but only some develop a substance use disorder. The increased risk might reflect heightened mesocorticolimbic responses to reward-related cues but results published to date have been inconsistent.
Methods: Young social drinkers (age 18.
Aversive social learning with a dead conspecific is achieved by Pavlovian conditioning in crickets.
Neurobiol Learn Mem
December 2024
Faculty of Science, Hokkaido University Sapporo 060-0810, Japan; Research Institute for Electronic Science, Hokkaido University, Sapporo 060-0812, Japan. Electronic address:
Social learning, learning from other individuals, has been demonstrated in many animals, including insects, but its detailed neural mechanisms remain virtually unknown. We showed that crickets (Gryllus bimaculatus) exhibit aversive social learning with a dead conspecific. When a learner cricket was trained to observe a dead cricket on a drinking apparatus, the learner avoided the odor of that apparatus thereafter.
View Article and Find Full Text PDFKetamine impairs the performance of male mice in novel recognition object test and reduces the immunoreactivity of GAD in the hippocampus: Role of pioglitazone.
Pharmacol Biochem Behav
December 2024
Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria, RS, Brazil. Electronic address:
Schizophrenia is a mental disorder characterized by positive, negative, and cognitive symptoms which is treated with antipsychotics. However, these drugs present several side effects and, some schizophrenia symptoms, like cognitive, are difficult to treat. The peroxisome proliferator-activated receptors-gamma (PPAR-γ) are expressed in dopaminergic neurons of the midbrain participating in the modulation of neurotransmitters release like dopamine.
View Article and Find Full Text PDFSchizophrenia is a multifaceted psychiatric disorder characterized by hallucinations, delusions, cognitive impairments, and behavioral disturbances. Genetic factors significantly contribute to its pathogenesis, accounting for approximately 80% of the heritability. Globally, about 1% of the population is affected by schizophrenia, with 45,054 individuals in Kazakhstan receiving medical treatment for the condition, indicating a prevalence rate of 238,6 per 100,000 people.
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