AI Article Synopsis
- Researchers have developed a new series of 14-membered macrolides with unique imidazo[4,5-b]pyridinyl sulfur side chains based on clarithromycin.
- The chemical transformation of the hydroxy group at position C-3 led to the creation of various ketolides and acylides.
- One particular compound, 15a, showed enhanced effectiveness in lab tests against both erythromycin-sensitive and resistant bacteria compared to telithromycin.
Article Abstract
In an effort to find new antibiotics, a novel series of 14-membered macrolides with imidazo[4,5-b]pyridinyl sulfur contained alkyl side chains has been synthesized based on commercially available clarithromycin. Chemical transformation of hydroxy group at position C-3 afforded range of ketolides and acylides. Compared to telithromycin, compound 15a demonstrated improved in vitro activity against erythromycin-susceptible and -resistant strains.
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| http://dx.doi.org/10.1016/j.bmcl.2009.06.023 | DOI Listing |
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