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The role of serendipity in our investigation of embryo implantation.
Dev Biol
January 2025
Department of Cell Biology, University of Virginia Health System, PO Box 800732 Charlottesville, VA 22908-0732. Electronic address:
Serendipity plays a huge role in science, and having a prepared mind that can seize upon a serendipitous observation or occurrence can drive a project forward. This happened in my lab with a project centered on the regulation of trophoblast cell behavior at implantation. We discovered that amino acids regulate the onset of trophoblast motility through the activation of the kinase complex mTORC1, and that this acts as a checkpoint to trophoblast differentiation.
View Article and Find Full Text PDFQuality Control and Validation Issues in LC-MS-Based Metabolomics.
Methods Mol Biol
January 2025
Division of Systems Medicine, Department of Metabolism Department of Metabolism, Digestion and Reproduction, Imperial College, London, UK.
Metabolic profiling performed using untargeted metabolomics of different, complex biological samples aims to apply agnostic/holistic, hypothesis-free, analysis of the small molecules that are present in the analyzed sample. This approach has been the center of major investments and dedicated efforts from the research community for many years. However, limitations and challenges remain, particularly with regard to the validation and the quality of the obtained results.
View Article and Find Full Text PDFSex and Gender Considerations in Orthopaedic Research: Existing Barriers, What's Needed by Institutions and Research Departments, and How to Guide Junior Investigators and Faculty.
J Bone Joint Surg Am
October 2024
Office of Research on Women's Health, National Institutes of Health, Bethesda, Maryland.
Article Synopsis
- The JBJS symposium focused on the importance of including sex and gender in orthopaedic research to enhance study methods and patient outcomes, addressing current shortcomings in reporting.
- Barriers to proper reporting stem from cultural resistance, inadequate education on terminology and study design, insufficient funding for larger studies, and the need for better understanding of how biological and social factors like gender and race interact in health research.
- To overcome these challenges, the development of best-practice statistical methods and ongoing education for all stakeholders in research is crucial, with existing guidelines like the SAGER providing a framework for improvement and support from academic institutions and funders being essential for meaningful progress.
Current status and perspectives of esophageal cancer: a comprehensive review.
Cancer Commun (Lond)
December 2024
Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, Guangdong, P. R. China.
Esophageal cancer (EC) continues to be a significant global health concern, with two main subtypes: esophageal squamous cell carcinoma and esophageal adenocarcinoma. Prevention and changes in etiology, improvements in early detection, and refinements in the treatment have led to remarkable progress in the outcomes of EC patients in the past two decades. This seminar provides an in-depth analysis of advances in the epidemiology, disease biology, screening, diagnosis, and treatment landscape of esophageal cancer, focusing on the ongoing debate surrounding multimodality therapy.
View Article and Find Full Text PDFWorldwide Sodium Channel Conference, January 31st-February 2nd, 2024, Grindelwald, Switzerland.
Bioelectricity
December 2024
York Biomedical Research Institute, Department of Biology, University of York, Heslington, UK.
The following is a brief report of the inaugural Worldwide Sodium Channels Conference, held in Grindelwald, Switzerland, in January 2024. This excellent in-person conference followed the highly successful online Worldwide Sodium Channel Seminars series which started following the COVID-19 pandemic, in 2021. We present here our highlights of the 45 presentations delivered over the two-and-a-half-day conference, focusing on key outputs from each of the eight sessions.
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