Objective: To investigate the expression of CLCA3 and Muc5ac in nasal mucosa in allergic rhinitis rats and the effects of glucocorticoid on its expression.
Methods: Thirty SD rats were randomly divided into allergic rhinitis group, dexamethasone group and control group. Expression of CLCA3 mRNA and Muc5ac protein in nasal mucosa were detected by RT-PCR and immunohistochemical assay, respectively.
Results: CLCA3 mRNA and Muc5ac protein in allergic rhinitis group were significantly higher than those in control group (t = 8.565, 5.317, P < 0.01, respectively). The increased expression of CLCA3 mRNA in allergic rhinitis group was well correlated with the expression of Muc5ac protein and the correlation coefficient was 0.813 (P < 0.05). After treatment with dexamethasone, the expression of CLCA3 mRNA and Muc5ac protein was notably lower than that in allergic rhinitis group (t = 3.102, 2.226, P < 0.05, respectively).
Conclusions: The stronger gene expression of CLCA3 exists, complicated with mucus overproduction in the nasal mucosa of allergic rhinitis rats. CLCA3 expression may play a pivotal role in mucus overproduction in allergic rhinitis. Dexamethasone substantially downregulates the expression of CLCA3 mRNA and Muc5ac protein.
Previous observational studies focused on the association of tea intake and allergic diseases. However, it is not known whether these associations are causal. We used a bidirectional Mendelian randomization (MR) study to assess the causal relationship of tea intake with the risk of allergic diseases, such as atopic dermatitis (AD), allergic rhinitis (AR), and allergic asthma (AA).
Neutrophils are short-lived cells of the innate immune system and represent 50-70% of the circulating leucocytes. Their primary role is antimicrobial defence which they accomplish through rapid migration to sites of inflammation followed by phagocytosis, degranulation and the release of neutrophil extracellular traps (NETosis). While previously considered terminally-differentiated cells, they have been shown to have great adaptability and to play a role in conditions ranging from cancer to autoimmunity.
Department of Scientific Research, Anhui Provincial Children's Hospital (Anhui Hospital, Children's Hospital of Fudan University), Hefei, Anhui 230051,China; Anhui Institute of Pediatric Research, Hefei, Anhui 230051, China; Children's Medical Center of Anhui Medical University, Hefei, Anhui 230032, China. Electronic address:
The relationship between air pollution exposure and non-allergic rhinitis (NAR) risk in children is underexplored and uncertain. Therefore, the impact of numerous air pollutants on the incidence of NAR in a Chinese pediatric population were investigated. Data on daily outpatient visits for NAR among children aged 0-18 years from 2015 to 2021 were obtained from Anhui Provincial Children's Hospital.
Background: Several epidemiological studies have shown that allergic rhinitis (AR) patients are more susceptible to coronavirus disease 2019 (COVID-19).
Objective: We aim to investigate the risk factors for COVID-19 in AR patients.
Methods: A retrospective nationwide cohort study was conducted based on a questionnaire survey in China.
