AI Article Synopsis
- ABCG1 is a cholesterol transporter that aids in the removal of cholesterol with the help of HDL, but its exact role in human atherosclerosis is not fully understood.* -
- The study investigated the impact of a specific mutation in the ABCG1 gene (-257T>G) on its transcription activity and assessed the genetic variation among 109 Japanese men with coronary artery disease (CAD).* -
- Findings revealed that the G allele of the mutation led to lower transcription activity of ABCG1, and it was associated with a higher severity of CAD, particularly in patients with multiple vessel disease.*
Article Abstract
Aim: ATP-binding cassette transporter G1 (ABCG1) is a cholesterol transporter that plays a role in cholesterol efflux in the presence of high-density lipoprotein (HDL). Moreover, HDL-mediated cholesterol efflux is increased in cultured ABCG1 overexpressed cells; however, the physiological roles of ABCG1 and its contribution to atherosclerosis in humans remain unclear.
Methods: The effect of ABCG1 -257T>G mutation on transcription activity was determined by a reporter assay. One hundred nine Japanese men with coronary artery disease (CAD) were analyzed. ABCG1 -257T>G polymorphism was assessed by mutation-selective PCR methods to identify T/T, T/G, and G/G genotypes.
Results: The reporter assay showed that ABCG1 transcription activity was significantly lower (p<0.01) in the G allele of -257T>G polymorphism compared with that in the T allele. Clinically, there were no significant differences in serum triglyceride and total, LDL, and HDL cholesterol levels, or other risk factors. Logistic regression analysis revealed significant additive and dominant effects on the frequency of patients with multi-vessel disease compared with single-vessel disease (T/T vs. T/G vs. G/G, odds ratio:2.1, p=0.027; T/T vs. T/G and. G/G, odds ratio:3.5, p=0.005).
Conclusion: This is the first report to show that a novel ABCG1 -257T>G promoter polymorphism influences CAD severity in Japanese men.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.5551/jat.e380 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Use of the FHTHWA Index as a Novel Approach for Predicting the Incidence of Diabetes in a Japanese Population Without Diabetes: Data Analysis Study.
JMIR Med Inform
January 2025
Department of Endocrinology and Metabolism, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Background: Many tools have been developed to predict the risk of diabetes in a population without diabetes; however, these tools have shortcomings that include the omission of race, inclusion of variables that are not readily available to patients, and low sensitivity or specificity.
Objective: We aimed to develop and validate an easy, systematic index for predicting diabetes risk in the Asian population.
Methods: We collected the data from the NAGALA (NAfld [nonalcoholic fatty liver disease] in the Gifu Area, Longitudinal Analysis) database.
Exploring factors associated with Kidney Disease Quality of Life in patients with advanced chronic kidney disease: the Reach-J CKD cohort study.
Clin Exp Nephrol
January 2025
Reach-J Steering Committee, Tsukuba, Ibaraki, Japan.
Background: Although several studies have examined the Kidney Disease Quality of Life (KDQOL) in patients with chronic kidney disease (CKD), the factors associated with kidney-related symptoms have not been fully explored.
Methods: This nationwide multicenter cohort study enrolled 2248 patients. To identify the factors associated with each item or the three KDQOL domains, such as burden of kidney disease, symptoms/problems of kidney disease, and impact of kidney disease on daily life, multiple regression analysis was performed using baseline data.
Introduction: Several anthropometric indices reflecting cardiometabolic risks have been developed, but the relationship of body composition with arterial stiffness remains unclear. We aimed to determine the interaction between age-related anthropometric changes and progression of arterial stiffness.
Methods: This research analyzed cross-sectional data (N=13,672) and 4-year longitudinal data (N=5,118) obtained from a healthy Japanese population without metabolic disorders.
Preferences for facial femininity/masculinity across culture and the sexual orientation spectrum.
J Exp Psychol Gen
January 2025
Department of Cognitive and Psychological Sciences, Nagoya University.
Judgments of attractiveness have many important social outcomes, highlighting the need to understand how people form these judgments. One aspect of appearance that impacts perceptions of attractiveness is facial femininity/masculinity (sexual dimorphism). However, extant research has focused primarily on White, Western, heterosexual participants' preferences for femininity/masculinity in White faces, limiting generalizability.
View Article and Find Full Text PDFNumber of teeth and incidence of hip fracture in older adults aged ≥75 years: the OHSAKA study.
J Epidemiol
January 2025
Health and Counseling Center, Osaka University.
Background: Several studies reported an association between the number of teeth and the incidence of hip fractures in observational studies, mainly in middle-aged adults. This retrospective cohort study aimed to clarify the association between the number of teeth and the incidence of hip fractures.
Methods: In this retrospective cohort study, a total of 256,772 participants aged 75 years or older who underwent public dental checkups in Japan were evaluated.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!