The aim of the research was to study the peculiarities of colonization of intestinal tract by Candida - in children with leukemia. It was found that in 32 out of 54 patients with leukaemia the quantity of intestinal KOE Candida in 1 g feces was correlated with the incidence of candidemia. The quantity of intestinal KOE/g Candida was higher in patients receiving antileukemic chemotherapy and antibacterial antibiotics than in normal subjects in patients with The quantity of Candida KOE/g feces was >10(5) cells per 1g of substrate. In control group this figure was within 10(3)-10(4). In all patients candidemia was revealed. In 8 patients who were not treated with antibiotics the quantity of Candida in feces was present to a less degree (<0.05). In the majority of cases (70%) in patients with leukaemia C.albicans was found, in 15% of cases - C. tropicalis. Along side with candidemia candidiazes of respiratory and urinary systems was revealed in children with leukaemia.
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Anim Sci J
January 2025
Guangxi Key Laboratory for Polysaccharide Materials and Modifications, School of Marine Sciences and Biotechnology, Guangxi Minzu University, Nanning, China.
The Citri Reticulatae Pericarpium (CRP), is the aged peel of Citrus fruit, which contains phenols, flavonoids, and polysaccharides. This study aims to investigate dietary CRP supplementation on the growth performance, serum biochemical indices, meat quality, intestinal morphology, microbiota, and metabolite of yellow-feathered broilers. A total of 240 yellow-feathered broilers (1.
View Article and Find Full Text PDFJ Toxicol Environ Health A
January 2025
School of Public Health, Hengyang Medical School, University of South China, Hengyang, China.
The global phenomenon of cyanobacterial bloom pollution is spreading globally due to climate change and eutrophication. It is well established that harmful cyanobacteria produce a wide range of toxins including microcystin-LR (MC-LR), a cyclic heptapeptide toxin known to damage various organs. The intestinal tract is the main site of MC-LR absorption and one of the targets susceptible to toxicity.
View Article and Find Full Text PDFBMC Microbiol
January 2025
Veterinary Research Institute, Hudcova 296/70, Brno, 621 00, Czech Republic.
Background: Gastrointestinal diseases in weaned piglets are a frequent cause of high morbidity and mortality in domestic pigs. The use of antibiotics is problematic due to increasing antibiotic resistance in bacterial populations, for which reason the use of suitable probiotics is highly recommended to maintain animal health and welfare.
Results: In this study, 57 strains of biologically safe lactic acid bacteria (LAB) and bifidobacteria originating from the gastrointestinal tract (GIT) of pigs were identified and characterized in terms of their probiotic properties for potential use in weaned piglets.
Nat Metab
January 2025
Department of Genetics, Stanford University, School of Medicine, Stanford, CA, USA.
The short-chain fatty acids (SCFAs) propionate and butyrate have beneficial health effects, are produced in large amounts by microbial metabolism and have been identified as unique acyl lysine histone marks. To better understand the function of these modifications, we used chromatin immunoprecipitation followed by sequencing to map the genome-wide location of four short-chain acyl histone marks, H3K18pr, H3K18bu, H4K12pr and H4K12bu, in treated and untreated colorectal cancer (CRC) and normal cells as well as in mouse intestines in vivo. We correlate these marks with open chromatin regions and gene expression to access the function of the target regions.
View Article and Find Full Text PDFSci Rep
January 2025
Department of General Surgery, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
The use of Santulli enterostomy (SE) for necrotizing enterocolitis (NEC) has been limited to a small number of studies involving a small number of patients and no control group. Our study aimed to compare the clinical safety and efficacy of Santulli enterostomy with those of single- or double-lumen enterostomy for neonatal NEC through a retrospective cohort study. One hundred ten patients who met the criteria were divided into an SE group (64 patients) and a conventional enterostomy (CE) group (46 patients).
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