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The Potency of Cytotoxic Mechanisms of Local Anesthetics in Human Chondrocyte Cells.
Int J Mol Sci
December 2024
Department of Biochemistry, National Defense Medical Center, Taipei 114, Taiwan.
Local anesthetics are commonly used in various clinical settings for both prevention and symptom relief. Numerous clinical studies have demonstrated that intra-articular injections of local anesthetics achieve high success rates in orthopedic practices. However, several widely used local anesthetics, including bupivacaine, lidocaine, and ropivacaine, have been shown to exhibit toxicity to chondrocytes, with the underlying mechanisms of chondrotoxicity remaining poorly understood.
View Article and Find Full Text PDFFactFinders for patient safety: Preventing local anesthetic-related complications: Local anesthetic chondrotoxicity and stellate ganglion blocks.
Interv Pain Med
December 2023
University of Utah School of Medicine, Departments of Physical Medicine & Rehabilitation, Salt Lake City, UT, USA.
This series of FactFinders presents a brief summary of the evidence and outlines recommendations to improve our understanding and management of several potential local anesthetic-related complications. Evidence in support of the following facts is presented. (1) -- There are drug-, concentration-, and time-dependent chondrotoxic effects that vary between local anesthetics.
View Article and Find Full Text PDFChondrotoxicity of Intra-Articular Injection Treatment: A Scoping Review.
Int J Mol Sci
June 2024
Rheumatology, S. Pietro Fatebenefratelli Hospital, 00189 Rome, Italy.
Article Synopsis
- The review looked at how some common drugs used in joint injections might harm cartilage in the body.
- Researchers found 185 articles, read many of them, and included 65 studies that met their rules.
- They discovered that some drugs like corticosteroids and certain local painkillers could be risky, while hyaluronic acid seems safer; more research is needed for other treatments like platelet-rich plasma.
Impact of gadolinium-based MRI contrast agent and local anesthetics co-administration on chondrogenic gadolinium uptake and cytotoxicity.
Heliyon
April 2024
Center for Orthopaedics, Trauma Surgery and Rehabilitation Medicine, University Medicine Greifswald, Germany.
The gadolinium-based contrast agent DOTA-Gd is clinically used in combination with local anesthetics for direct magnetic resonance arthrography. It remains unclear whether gadolinium uptake into cartilage is influenced by co-administration of bupivacaine or ropivacaine and whether DOTA-Gd alters their chondrotoxicity. Gadolinium quantification of chondrogenic spheroids revealed enhanced gadolinium uptake after simultaneous exposure to local anesthetics.
View Article and Find Full Text PDFReview of intra-articular local anaesthetic administration in horses: Clinical indications, cytotoxicity, and outcomes.
Equine Vet J
September 2024
Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA.
Equine practitioners frequently inject local anaesthetics (LA) intra-articularly in both diagnosis of lameness and for pain management intra- or post-operatively with synovial endoscopy. Recent reviews of the human and veterinary literature support the concept that chondrotoxicity of LA on joint tissues depends on the type of drug, dose administered, and duration of exposure. The purpose of this review is to summarise the current literature describing intra-articular local anaesthetic use, including both in vitro and in vivo studies, and to draw some comparisons to literature from other species where potential toxicity and duration of effect have been evaluated with the goal of advancing the field's understanding of intra-articular local anaesthetic use in horses, and indicating future directions for the field.
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