Novel spiroborate esters derived nonracemic 1,2-aminoalcohols and ethylene glycol are reported as highly effective catalysts for the asymmetric borane reduction of a variety of prochiral ketones with borane-dimethyl sulfide complex at room temperature. Optically active alcohols were obtained in excellent chemical yields using 0.1 to 10 mol % of catalysts with up to 99% ee.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701200 | PMC |
| http://dx.doi.org/10.1016/j.tetlet.2007.06.086 | DOI Listing |
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