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Reported prevalence and comparison of diagnostic approaches for Candida africana: a systematic review with meta-analysis.
Diagn Progn Res
December 2024
The African Centre of Excellence in Bioinformatics and Data-Intensive Sciences, Infectious Diseases Institute, Makerere University, P.O. Box 22418, Kampala, Uganda.
This systematic review and meta-analysis evaluated reported prevalence and diagnostic methods for identifying Candida africana, an opportunistic yeast associated with vaginal and oral candidiasis. A comprehensive literature search yielded 53 studies meeting the inclusion criteria, 2 of which were case studies. The pooled prevalence of C.
View Article and Find Full Text PDFMicrobiota of Urine, Glans and Prostate Biopsies in Patients with Prostate Cancer Reveals a Dysbiosis in the Genitourinary System.
Cancers (Basel)
February 2023
Division of Microbiology, Department of Pathology, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal.
Prostate cancer (PCa) is the most common malignant neoplasm with the highest worldwide incidence in men aged 50 years and older. Emerging evidence suggests that the microbial dysbiosis may promote chronic inflammation linked to the development of PCa. Therefore, this study aims to compare the microbiota composition and diversity in urine, glans swabs, and prostate biopsies between men with PCa and non-PCa men.
View Article and Find Full Text PDFAntiretroviral drug exposure in urethral and glans surface sampling of the penis.
J Antimicrob Chemother
August 2021
Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Article Synopsis
- A study was conducted to evaluate the distribution of antiretroviral (ARV) drugs in penile tissues among 35 HIV-negative males after a single dose of a combination medication that includes tenofovir alafenamide, emtricitabine, elvitegravir, darunavir, and cobicistat.
- * Researchers collected swabs from the urethra, glans, rectum, blood, and urine up to 96 hours post-dosing to measure ARV concentrations using a specialized detection method.
- * Results indicated that emtricitabine and darunavir had significant peak concentrations in urethral and glans swabs, suggesting they may provide a protective effect against HIV acquisition through penile tissue, while
Microorganisms and Antibiotic Profile of the Subpreputial Space in Uncircumcised Boys.
Urol J
November 2020
Department of Urology, The Ministry Of Health, University of Health Sciences, Van Education and Research Hospital, Van 65000, Turkey.
Purpose: This study investigates the frequency of isolated microorganisms and the antimicrobial resistant pattern of inner foreskin and smegma in prepubertal children.
Materials And Methods: This comparative cross-sectional study was conducted between March and November 2019, where 132 prepubertal boys, who were scheduled to receive religious circumcisions at our outpatient clinic, were examined. The patients were divided into the following groups based on the presence of smegma in their subpreputial space: Group I (with smegma, n=58) and Group II (without smegma, n=74).
Foreskin surface area is not associated with sub-preputial microbiome composition or penile cytokines.
PLoS One
August 2020
Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Objective: Male circumcision (MC) reduces acquisition of HIV-1 in heterosexual men by at least 60%, but the biological mechanism for this protection is incompletely understood. Previous studies have shown that a larger foreskin size, increased abundance of anaerobic bacteria in the sub-preputial space, and higher levels of pro-inflammatory cytokines on the penis are all prospectively associated with risk of HIV-1 acquisition. Since coverage of the glans on the non-erect penis is dependent on foreskin size, a larger foreskin could result in a less aerobic environment that might preferentially support anaerobic bacterial growth and induce inflammation.
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