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Neglected class A carbapenemases: Systematic review of IMI/NmcA and FRI from a One Health perspective.
Sci Total Environ
January 2025
Laboratoire de Bactériologie, Centre Hospitalier Universitaire de Montpellier, Montpellier, France; UMR MIVEGEC, Université de Montpellier, IRD, CNRS, Montpellier, France.
Carbapenemase-producing Enterobacterales are pathogens classified as a critical priority by the World Health Organization and a burden on human health worldwide. IMI, NmcA, and FRI are under-detected class A carbapenemases that have been reported in the human, animal and environmental compartments, particularly these last 5 years. Bacteria producing these carbapenemases have been mostly identified in digestive carriage screenings, but they are also involved in severe infections, such as bacteremia.
View Article and Find Full Text PDFLength of hospital stay not affected by empirical treatment with ceftriaxone versus cefuroxime for bacteraemia.
Acta Paediatr
January 2025
Pediatric Department, Laniado Hospital, Netanya, Israel.
Aim: The preferred antibiotic treatment for bacteraemia in infants continues to be debated. We examined the duration of hospital stays as a surrogate for the effectiveness of initial treatment with ceftriaxone versus cefuroxime.
Methods: This was a retrospective review of the medical records of all infants aged 3-36 months, admitted with suspected occult bacteraemia to the paediatric department at Laniado Hospital, Israel, between 2016 and 2022.
Health state utilities associated with invasive pneumococcal disease, pneumonia, and recurrent acute otitis media in young children.
Qual Life Res
January 2025
MRL, Merck & Co., Inc., Rahway, NJ, USA.
Purpose: Cost-utility analyses examining the value of new vaccines for pneumococcal disease will require health state utilities as inputs. Existing utilities for pneumococcal infections in young children are limited. The purpose of this study was to estimate health state utilities associated with pneumococcal infections in young children.
View Article and Find Full Text PDFOptimizing Management of Febrile Young Infants Without Serum Procalcitonin.
Pediatrics
January 2025
Departments of Pediatrics and Emergency Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC.
Background: Febrile young infants are at risk of invasive bacterial infections (IBIs; bacteremia or bacterial meningitis). American Academy of Pediatrics (AAP) guidelines recommend that when procalcitonin testing is unavailable, C-reactive protein (CRP), absolute neutrophil count (ANC) and temperature should be used to identify low-risk infants. We sought to determine the optimal combination of these inflammatory markers to predict IBI when procalcitonin is unavailable.
View Article and Find Full Text PDFCase report: A rare case of bacteremia in an immunocompetent psychiatric patient: exploring the links between mental health and infectious diseases.
Front Immunol
January 2025
Department of Hepatobiliary Surgery, Panzhihua Central Hospital, Sichuan, China.
This study aims to explore the pathogenic potential of as a rare pathogen in immunocompetent individuals and to analyze how mental health status may influence susceptibility to infection. We report a case of bacteremia in a 31-year-old immunocompetent female who developed infection during an episode of severe depression. Although the patient exhibited self-harm tendencies, a thorough physical examination did not reveal any external wounds or signs of injury.
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