An optical sensor for quantitative analysis of ultrathin films and adsorbed layers is described. Quantification of both layer thickness and refractive index (density) can be made for in situ and ex-situ coated films. With the use of two polarizations, in situ measurements are made via one path length in a young's interferometer arrangement while ex-situ measurements use multiple path lengths. The multiple path length young's interferometer arrangement is embodied in a solid state waveguide configuration called the multiple path length dual polarization interferometer (MPL-DPI). The technique is demonstrated with ultrathin layers of poly(methylmethacrylate) and human serum albumin.
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http://dx.doi.org/10.1364/oe.17.010959 | DOI Listing |
To accurately model the specific detection characteristics of spectral sensors based on linear variable filters (LVFs) within an optical design tool, it is essential to consider crucial position-variable spectral properties, such as peak transmittance, central wavelength, half width, or slope steepness. In this context, we propose a straightforward approach, integrating a dynamic link library (DLL) containing all position-dependent spectral properties of the LVF into a commercial optical design software. Exemplary investigations are conducted for an LVF with a detection range of 450-850 nm.
View Article and Find Full Text PDFProtein Sci
February 2025
MOE Key Laboratory of Bioinformatics, School of Life Sciences, Tsinghua University, Beijing, China.
An important step of mainstream protein structure prediction is to model the 3D protein structure based on the predicted 2D inter-residue geometric information. This folding step has been integrated into a unified neural network to allow end-to-end training in state-of-the-art methods like AlphaFold2, but is separately implemented using the Rosetta folding environment in some traditional methods like trRosetta. Despite the inferiority in prediction accuracy, the conventional approach allows for the sampling of various protein conformations compatible with the predicted geometric constraints, partially capturing the dynamic information.
View Article and Find Full Text PDFMicrosc Res Tech
January 2025
Faculty of Dental Medicine, Grigore T. Popa University of Medicine and Pharmacy, Iasi, Romania.
One area of technological advancement has been the shift from stainless steel hand tools to nickel-titanium (Ni-Ti) rotary tools. This paper aims to perform an in vitro comparative study to evaluate the efficacy of five endodontic manual and rotary instruments such as Kerr files, Orodeka Plex V, ProTaper Flydent NiTi super files, and ProTaper Flydent NiTi super files in combination with an ultrasonic endodontic E3D Diamantata EMS scaler used for root canal shaping. The following aspects were highlighted: effective removal of smear layer (SL) from the dentinal tubules in the coronal 1/3, middle 1/3, and apical 1/3 of the root canal, appearance of cracks in the dentinal walls by SEM analysis, and highlighting of dentin mineral content and remnant debris by EDX analysis.
View Article and Find Full Text PDFGerontologist
January 2025
Photozig, Inc., Moffett Field, CA, USA.
Background And Objectives: The study seeks to elucidate the pathways by which the Caregiver TLC psycho-educational program impacts the psychological health of caregivers by examining the degree to which changes in self-efficacy, personal gains, and emotional support mediate the changes on perceived depression, anxiety and burden.
Research Design And Methods: Using pre-post data from the Caregiver TLC randomized controlled trial (n = 81) for each outcome and mediator pair, a series of multiple regression models were executed to test the degree to which the program's total effects on changes in depression, burden and anxiety from baseline to post-intervention are due to changes in each mediator variable from pre- and post-intervention assessments. Caregivers were primarily female (85%), White (62 %), Black (38%), with a median age of 62 and household income of $75,000+.
Small Methods
January 2025
College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang, 050018, P. R. China.
Asymmetric carbon-based materials (ACBMs) have received significant attention in scientific research due to their unique structures and properties. Through the introduction of heterogeneous atoms and the construction of asymmetric ordered/disordered structures, ACBMs are optimized in terms of electrical conductivity, pore structure, and chemical composition and exhibit multiple properties such as hydrophilicity, hydrophobicity, optical characteristics, and magnetic behavior. Here, the recent research progress of ACBMs is reviewed, focusing on the potential of these materials for electrochemical, catalysis, and biomedical applications and their unique advantages over conventional symmetric carbon-based materials.
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