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Epstein-Barr Virus-Positive Primary Central Nervous System Lymphoma in Adult-Onset Still's Disease: A Case Report.
Mediterr J Rheumatol
December 2024
Department of Endocrinology and Rheumatology, Kurashiki Central Hospital, Okayama, Japan.
From prediction to practice: mitigating bias and data shift in machine-learning models for chemotherapy-induced organ dysfunction across unseen cancers.
BMJ Oncol
November 2024
Department of Computer Science, Durham University, Durham, UK.
Objectives: Routine monitoring of renal and hepatic function during chemotherapy ensures that treatment-related organ damage has not occurred and clearance of subsequent treatment is not hindered; however, frequency and timing are not optimal. Model bias and data heterogeneity concerns have hampered the ability of machine learning (ML) to be deployed into clinical practice. This study aims to develop models that could support individualised decisions on the timing of renal and hepatic monitoring while exploring the effect of data shift on model performance.
View Article and Find Full Text PDFIntroduction: Lymphoma is a common malignancy among adolescents and young adults (AYAs) which is generally defined as 15-39 years. Relative to other age groups, lymphoma in AYAs remains understudied with heterogeneous treatment options.
Methods: We performed a retrospective review of patients aged 18-60 years in the Australasian Lymphoma and Related Diseases Registry (LaRDR) with new diagnoses of the common subtypes of lymphoma in AYAs between January 2016 and April 2023.
ATP Binding and Inhibition of Intrinsically Disordered Protein Interactions.
Langmuir
January 2025
Zhejiang Province Key Laboratory of Quantum Technology and Device, School of Physics, Zhejiang University, Yuhangtang Road 866, Hangzhou 310058, China.
Recent studies have shown that ATP at high physiological concentrations (>5 mM) can inhibit liquid-liquid phase separation (LLPS) driven by interactions between intrinsically disordered proteins (IDPs). However, the mechanism underlying such inhibitory effect still remains elusive. Here, we used all-atom molecular dynamics simulation to study the interaction of ATP with two typical IDPs (i.
View Article and Find Full Text PDFPhysical effects of crowdant size and concentration on collective microtubule polymerization.
Biophys J
January 2025
Div. of Biology, IISER Pune, Dr. Homi Bhabha Road, Pashan, Pune 411008, India. Electronic address:
The polymerization of cytoskeletal filaments is regulated by both biochemical pathways, as well as physical factors such as crowding. The effect of crowding in vivo emerges from the density of intracellular components. Due to the complexity of the intracellular environment, most studies are based on either in vitro reconstitution or theory.
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