AI Article Synopsis
- Most studies on human telomeres have concentrated on the overall telomere length in cells rather than individual chromosome arms.
- This study aimed to explore how the size of chromosome arms relates to the length of their corresponding telomeres using a method called Quantitative Fluorescence In Situ Hybridization (Q-FISH).
- The researchers found a positive correlation (r = 0.6) between telomere length and chromosome arm size in 17 individuals, suggesting that larger chromosome arms tend to have longer telomeres.
Article Abstract
The majority of human telomere length studies have focused on the overall length of telomeres within a cell. In fact, very few studies have examined telomere length for individual chromosome arms. The objective of this study was to examine the relationship between chromosome arm size and the relative length of the associated telomere. Quantitative Fluorescence In Situ Hybridization (Q-FISH) was used to measure the relative telomere length of each chromosome arm in metaphases from cultured lymphocytes of 17 individuals. A statistically significant positive correlation (r = 0.6) was found between telomere length and the size of the associated chromosome arm, which was estimated based on megabase pair measurements from (http://www.ncbi.nlm.nih.gov/projects/mapview/).
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695537 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0006013 | PLOS |
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