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Co-delivery of siBcl-2 and PTX with mitochondria-targeted functions to overcoming multidrug resistance.
Int J Pharm
April 2024
College of Pharmacy, Nantong University, Nantong 226001, PR China. Electronic address:
Multidrug resistance (MDR) poses a significant impediment to the efficacy of chemotherapy in clinical settings. Despite Paclitaxel (PTX) being designated as the primary pharmaceutical agent for treating recurrent and metastatic breast cancer, the emergence of PTX resistance frequently results in therapeutic shortcomings, representing a substantial obstacle in clinical breast cancer management. In response, we developed a delivery system exhibiting dual specificity for both tumors and mitochondria.
View Article and Find Full Text PDFDesign, Synthesis, Insecticidal Activities and Molecular Docking of Sulfonamide Derivatives Containing Propargyloxy or Pyridine Groups.
Chem Biodivers
February 2023
College of Chemistry & Pharmacy, Northwest A&F University, Xian Yang Shi, Yangling, 712100, China.
Article Synopsis
- Researchers discovered new, effective insecticides from natural products, focusing on Celangulin V, which targets a specific enzyme in insects.
- They synthesized thirty-seven sulfonamide derivatives to find cost-effective compounds with high insecticidal efficiency.
- Several derivatives showed better insecticidal activity against larvae than Celangulin V, providing potential new insecticide options based on their unique mechanism of action.
Design, synthesis and insecticidal activity of benzenesulfonamide derivatives containing various alkynyl, alkenyl and cyclopropyl groups in para position.
Nat Prod Res
January 2024
College of Chemistry & Pharmacy, State Key Laboratory of Crop Stress Biology for Arid Areas, Northwest A&F University, Yangling, China.
Article Synopsis
- Celangulin V, a natural sesquiterpene polyester, has shown anti-insect activity through a unique mechanism targeting the H subunit of V-ATPase in insect midguts.
- Researchers synthesized thirty-two benzene sulfonamide derivatives to find cost-effective insecticides, with several compounds (C2, C4, C5, C6, and C8) demonstrating significantly higher efficacy than Celangulin V, with lower LC50 values.
- Molecular docking studies suggest that these new sulfonamide compounds effectively interact with the H subunit of V-ATPase, making them promising candidates for developing efficient insecticidal agents.
Insight into the Mode of Action of Celangulin V on the Transmembrane Potential of Midgut Cells in Lepidopteran Larvae.
Toxins (Basel)
December 2017
College of Plant Protection, Northwest A&F University, Yangling 712100, China.
Celangulin V (CV) is the main insecticidal constituent of . The V-ATPase H subunit of the midgut cells of lepidopteran larvae is the putative target protein of CV. Here, we compared the effects of CV on the midgut membrane potentials of and larvae with those of the Cry1Ab toxin from and with those of inactive CV-MIA, a synthetic derivative of CV.
View Article and Find Full Text PDFMolecular Insights into the Potential Insecticidal Interaction of β-Dihydroagarofuran Derivatives with the H Subunit of V-ATPase.
Molecules
October 2017
College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, Shaanxi, China.
Celangulin V (CV), one of dihydroagarofuran sesquiterpene polyesters isolated from Chinese bittersweet ( Maxim), is famous natural botanical insecticide. Decades of research suggests that is displays excellent insecticidal activity against some insects, such as Walker. Recently, it has been validated that the H subunit of V-ATPase is one of the target proteins of the insecticidal dihydroagarofuran sesquiterpene polyesters.
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