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Impact of Genetic Polymorphisms on Electrochemical Parameters and Acid-Base Disorders in Brazilian Runners During a 105-Kilometer Ultramarathon.
Nutrients
November 2024
Postgraduate Program in Physical Education, Universidade Tecnológica Federal do Paraná, Curitiba 81310900, Brazil.
Article Synopsis
- The study investigated 22 elite male mountain runners from Brazil, focusing on how specific genetic variants affect their performance and physiological responses during a 105-km ultramarathon.
- Genotyping was done using saliva samples to analyze the ACTN3 R577X, ACE I/D, and CK MM A/G NcoI polymorphisms, and real-time measures of electrochemical and acid-base balance were recorded.
- Results indicated that certain genotypes correlated with differences in potassium levels, hematocrit values, and pH, suggesting that these genetic variations play a significant role in athletes' physiological responses during extreme endurance events.
Discriminating three lab scale dark chocolate bars from fine Cameroon cocoa hybrids using sensorial evaluation and organic acid content.
J Food Sci Technol
December 2024
Biotechnology Centre, University of Yaounde I, Etetak, P.O. Box 17673, Yaounde, Cameroon.
Previous studies have shown a correlation between chocolate sensory profile and certain (bio)chemical components. The aim of this study was to examine the sensorial profile and organic acid content of three lab scale chocolate brands produced from different cocoa genotypes. The sensorial evaluation was examined by a team of 12 panelists and evaluation of aroma volatiles was done by means of HS-SPME-GC-MS.
View Article and Find Full Text PDFApplication of smart-responsive hydrogels in nucleic acid and nucleic acid-based target sensing: A review.
Biosens Bioelectron
January 2025
School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang, 212003, Jiangsu Province, PR China; Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, 117543, Singapore. Electronic address:
In recent years, nucleic acid-related sensing and detection have become essential in clinical diagnostics, treatment and genotyping, especially in connection with the Human Genome Project and the COVID-19 pandemic. Many traditional nucleic acid-related sensing strategies have been employed in analytical chemistry, including fluorescence, colorimetric and chemiluminescence methods. However, their key limitation is the lack of understanding of the interaction during analysis, particularly at the 3D matrix level close to biological tissue.
View Article and Find Full Text PDFSub-chronic nicotine exposure influences methamphetamine self-administration and dopamine overflow in a sex-and genotype-dependent manner in humanized 6 3'-UTR SNP (rs2304297) adolescent rats.
Front Pharmacol
August 2024
Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, CA, United States.
The rewarding effects of drugs of abuse are associated with the dopaminergic system in the limbic circuitry. Nicotine exposure during adolescence is linked to increased use of drugs of abuse with nicotine and methamphetamine (METH) commonly used together. Nicotine acts on neuronal nicotinic acetylcholine receptor (nAChR) systems, critical for reward processing and drug reinforcement, while METH leads to a higher dopamine (DA) efflux in brain reward regions.
View Article and Find Full Text PDFMicrofluid biosensor for detection of hpv in patient scraping samples: Determining E6 and E7 oncogenes.
Bioelectrochemistry
December 2024
Programa de Pós-Graduação em Inovação Terapêutica, Universidade Federal de Pernambuco, 50670-901 Recife, PE, Brazil; Laboratório de Biodispositivos Nanoestruturados, Departamento de Bioquímica, Universidade Federal de Pernambuco, 50670-901 Recife, PE, Brazil. Electronic address:
E6 and E7 oncogenes are pivotal in the carcinogenic transformation in HPV infections and efficient diagnostic methods can ensure the detection and differentiation of HPV genotype. This study describes the development and validation of an electrochemical, label-free genosensor coupled with a microfluidic system for detecting the E6 and E7 oncogenes in cervical scraping samples. The nanostructuring employed was based on a cysteine and graphene quantum dots layer that provides functional groups, surface area, and interesting electrochemical properties.
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