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Effect of time and temperature on the stability of HPV and cellular nucleic acid using simulated dry self-samples.
J Virol Methods
December 2024
Scottish HPV Reference Laboratory, NHS Lothian, Royal Infirmary of Edinburgh, Little France, Edinburgh EH16 4SA, United Kingdom; HPV Research Group, University of Edinburgh, Edinburgh EH16 4TJ, United Kingdom.
Background: Self-sampling is now a key component within HPV-based cervical screening programmes to engage individuals and enhance participation. As self-sampling is relatively new, information on the influence of pre-analytical parameters such as transit-temperature and time between sampling and testing on HPV test results requires detailed investigation.
Methods: FLOQSwabs® and Evalyn Brushes® were used to assess HPV and cellular stability over a 30-week period (0w,4w,12w,30w) at 4 °C, ambient, and 37 °C.
Stability of the thromboxane B biomarker of low-dose aspirin pharmacodynamics in human whole blood and in long-term stored serum samples.
Res Pract Thromb Haemost
November 2024
Department of Healthcare Surveillance and Bioethics, Section of Pharmacology, Catholic University School of Medicine, Rome, Italy.
Background: Serum thromboxane B (sTXB) is a validated biomarker of low-dose aspirin pharmacodynamics. In the original method, nonanticoagulated blood samples must be incubated at 37 °C immediately after withdrawal, centrifuged and serum supernatant should be frozen until assayed. Timely completion of all preanalytical steps may affect the feasibility and quality of sTXB measurements.
View Article and Find Full Text PDFAcid-base parameters in venous blood - agreement between values from safePICO syringes and lithium-heparin vacutainer tubes.
Scand J Clin Lab Invest
December 2024
Department of Clinical Biochemistry, Gødstrup Hospital, Herning, Denmark.
Venous blood is considered an acceptable alternative to arterial blood for assessment of metabolic acid-base disorders. Also, venous sampling using lithium-heparin (Li-Hep) tubes is advantageous to arterial sampling using PICO syringes, the risk of complications being lower. Usage of partly filled tubes without firm knowledge about the clinical consequences is, however, a pre-analytic consideration.
View Article and Find Full Text PDFOverview of a comparative analysis of microsatellite instability and standard mismatch repair protein-deficiency tests in a large cancer cohort.
Pathologie (Heidelb)
December 2024
Department of Pathology, Forensic and Insurance Medicine, Semmelweis University, Budapest, Hungary.
Article Synopsis
- Mismatch repair deficiency (dMMR) and microsatellite instability (MSI) are important genetic markers in various cancers, especially gastrointestinal and endometrial types, and can indicate responsiveness to immune checkpoint inhibitors (ICIs).
- In a study involving 1,306 cancer cases, dMMR was determined through immunohistochemistry (IHC) testing for specific proteins, while MSI was assessed using pentaplex PCR, revealing an overall MSI-high incidence of 12.1% compared to a dMMR incidence of 20.3%.
- A significant discrepancy of 19.3% was found between dMMR and MSI results, particularly noted with a 60.9% discrepancy in
Pre-analytical stability of haematinics, lactate dehydrogenase and phosphate in whole blood at room temperature up to 24 h, and refrigerated serum stability of lactate dehydrogenase, folate and vitamin B12 up to 72 h using the CRESS checklist.
Clin Chem Lab Med
December 2024
Blood Sciences, 8930 NHS Highland, Raigmore Hospital, Inverness, Scotland, UK.
Objectives: There is a lack of analyte stability data in whole blood (WB). The aim of this study was to determine the allowable delay in WB processing for lactate dehydrogenase (LDH), folate, vitamin B12, iron and phosphate measurement. The stability of LDH, folate and vitamin B12 was also assessed in stored serum at clinically relevant time points.
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