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Modeling Malignant Mesothelioma in Genetically Engineered Mice.
Curr Protoc
January 2025
Cancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
Mesothelioma is a lethal cancer of the serosal lining of the body cavities. Risk factors include environmental and genetic factors. Asbestos exposure is considered the principal environmental risk factor, but other carcinogenic mineral fibers, such as erionite, also have a causal role.
View Article and Find Full Text PDFAsbestos-related diseases in Africa: sentinel cases of mesothelioma and asbestosis from DR Congo.
Pulmonology
December 2025
Department of Public Health and Primary Care, Centre for Environment and Health, KU Leuven, Leuven, Belgium.
Bayesian analysis of the rate of spontaneous malignant mesothelioma among BAP1 mutant mice in the absence of asbestos exposure.
Sci Rep
January 2025
ArrayXpress, Inc., Raleigh, NC, USA.
Cancers of the mesothelium, such as malignant mesothelioma (MM), historically have been attributed solely to exposure to asbestos. Recent large scale genetic and genomic functional studies now show that approximately 20% of all human mesotheliomas are causally linked to highly penetrant inherited (germline) pathogenic mutations in numerous cancer related genes. The rarity of these mutations in humans makes it difficult to perform statistically conclusive genetic studies to understand their biological effects.
View Article and Find Full Text PDFAdvancing Health Equity Metrics: Estimating the Burden of Lung Cancer Attributed to Known Carcinogens by Socio-economic Position.
Am J Epidemiol
December 2024
Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, F-35000 Rennes, France.
Attributable burden of disease estimates reported population-wide do not reflect social disparities in exposures and outcomes. This makes one of the influential scientific tools in public health decision-making insensitive to the distribution of health impacts between socioeconomic groups. Our aim was to use the often-overlooked distributive property of the population attributable fraction (PAF) to quantitatively partition the population burden attributed to know risk factors into subgroups defined by their socioeconomic position (SEP).
View Article and Find Full Text PDF[Mortality due to mesothelioma and asbestosis in Campania Region (Southern Italy): perspectives for reducing asbestos exposure].
Epidemiol Prev
December 2024
Dipartimento di Medicina, Epidemiologia, Igiene del lavoro e ambientale, Istituto Nazionale per l'Assicurazione contro gli Infortuni sul Lavoro, Roma.
Objectives: to provide an overview of the geographical distribution of mesothelioma and asbestosis deaths in the Campania Region (Southern Italy) occurred from 2005 to 2018 and to identify areas at higher risk.
Design: for each municipality, Standardized Mortality Ratios (SMRs) for mesothelioma and asbestosis have been estimated from the mortality data provided by the Italian National Institute of Statistics (Istat). Deaths for which mesothelioma and asbestosis were identified as the underlying causes, according to the classification system ICD-10 codes (C45 and J61, respectively), were included.
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