A bipolar patient with renal angiosclerosis due to lithium intoxication showed convulsive crises for about four months after each haemodialysis session. Aetiological work up was not able to isolate a unique cause, but modifications in treatment relieved the symptoms.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.encep.2008.08.001 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Decreased neuronal excitability in hypertriglyceridemia hamsters with acute seizures.
Front Neurol
December 2024
Department of Pediatrics, Peking University First Hospital, Beijing, China.
Introduction: Neonatal seizures are the most common clinical manifestation of neurological dysfunction in newborns, with an incidence ranging from 1 to 5‰. However, the therapeutic efficacy of current pharmacological treatments remains suboptimal. This study aims to utilize genetically modified hamsters with hypertriglyceridaemia (HTG) to investigate the effects of elevated triglycerides on neuronal excitability and to elucidate the underlying mechanisms.
View Article and Find Full Text PDFBaclofinding solutions: Baclofen-induced encephalopathy in a peritoneal dialysis patient.
Perit Dial Int
January 2025
Department of Medicine, Johns Hopkins Aramco Healthcare Center, Dhahran, Saudi Arabia.
Baclofen is a gamma-aminobutyric acid agonist that is commonly and widely used for the treatment of muscle spasticity. Given its predominant kidney excretion, patients with reduced kidney function are at particular risk of drug accumulation and toxicity, with neurotoxicity in the form of drowsiness, encephalopathy, seizures, and coma being the most reported clinical features. In addition to the importance of early identification of baclofen toxicity and drug discontinuation, dialysis can effectively accelerate baclofen elimination given its small molecule weight, and the relatively low volume of distribution and weak protein binding.
View Article and Find Full Text PDFBackground: Atypical Hemolytic Uremic Syndrome (aHUS) is categorized as a thrombotic microangiopathy (TMA), which arises due to abnormal or unregulated complement pathway activation. While the disease frequently affects renal blood vessels, it can also involve multiple other organ systems. This review examines the prevalence and clinical outcomes of aHUS patients with extrarenal involvement.
View Article and Find Full Text PDFNeurosurgical Outcomes for Intracerebral Hemorrhage in Patients Undergoing Dialysis.
Life (Basel)
October 2024
Department of Cerebrovascular Surgery, Saitama Medical University International Medical Center, Hidaka 350-1298, Japan.
Article Synopsis
- * A study of 38 HD patients who underwent surgery found that a majority (78.9%) had poor outcomes at discharge, and significant differences were noted in Glasgow Coma Scale (GCS) scores and hematoma volumes between patients with better and very poor outcomes.
- * Despite the overall poor surgical outcomes, 21.1% of patients achieved a favorable modified Rankin Scale (mRS) score of 4 or less; patients with a GCS > 9 or hemat
Valproate-induced hyperammonemic encephalopathy in neurosurgical patients: Our experience and systematic literature review.
Neurosurg Rev
November 2024
Department of Neurosurgery, Neurosciences Centre, All India Institute of Medical Sciences, New Delhi, India.
Article Synopsis
- Sodium valproate is commonly used to treat seizures, chronic pain, and bipolar disorder, but it can cause severe side effects like valproate-induced hyperammonemic encephalopathy (VHE), which is life-threatening.
- A study reviewed four neurosurgical patients who developed VHE after using valproate for seizure prevention, revealing a 50% mortality rate and indicating that prompt diagnosis and treatment are crucial.
- Treatment involved discontinuing valproate and, in some cases, dialysis; half of the patients experienced clinical improvement after normalization of ammonia levels.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!