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Identification of association between mitochondrial dysfunction and sarcopenia using summary-data-based Mendelian randomization and colocalization analyses.
J Gerontol A Biol Sci Med Sci
January 2025
Department of Joint Surgery, HongHui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Background: Mitochondrial dysfunction has been demonstrated to be an important hallmark of sarcopenia, yet its specific mechanism remains obscure. In this study, mitochondrial-related genes were used as instrumental variables to proxy for mitochondrial dysfunction, and summary data for sarcopenia-related traits were used as outcomes to examine their genetic association.
Methods: A total of 1,136 mitochondrial-related genes from the human MitoCarta3.
Should an Interval Appendicectomy Be Performed by a Minimally Invasive Gynaecologist?
Int J Womens Health
December 2024
Sydney Women's Endosurgery Centre (SWEC), St George Hospital, Sydney, NSW, Australia.
Objective: We aimed to explore the abnormal pathology findings in appendix specimens removed based on intraoperative abnormal appearance during elective surgery for benign gynaecological conditions by a minimally invasive gynaecologist, as well as the associated complication rate.
Materials And Methods: This retrospective cohort study was conducted in a tertiary referral surgical centre for benign gynaecological conditions between the years 2004-2023. It included patients who underwent appendicectomy by a trained minimally invasive gynaecologist based on observations during surgery for benign gynaecological conditions.
Low-grade appendiceal mucinous neoplasm: A case report.
Medicine (Baltimore)
December 2024
Department of General Surgery, Nujiang Prefecture People's Hospital, Nujiang, Yunnan, China.
Rationale: Low-grade appendiceal mucinous neoplasm (LAMN) is a clinically rare tumor that predominantly occurs in females and presents with nonspecific symptoms, often resulting in misdiagnosis. While postoperative pathology remains the gold standard for diagnosis, accurate preoperative identification through various diagnostic methods is essential for effective treatment planning. To raise awareness of this condition, we present a case of a middle-aged male diagnosed with LAMN.
View Article and Find Full Text PDFAcellular Appendix Vermiform Mucinous Neoplasm.
Case Rep Pathol
December 2024
Department of Obstetrics and Gynecology, Democritus University of Thrace, Alexandroupolis, Greece.
Appendiceal neoplasms are usually asymptomatic or associated with mild, nonspecific symptoms. Due to the rarity of the disease and the lack of specific symptoms, this clinical entity escapes the diagnostic consideration of the gynecologist, when women come in with right iliac fossa pain. A case is presented of a 56-year-old woman with a mass in the right small pelvis, which was preoperatively diagnosed as originating from the ovary.
View Article and Find Full Text PDFIntraperitoneal "golden yellow" in a pediatric patient with Burkitt lymphoma: Xanthogranulomatous appendicitis.
North Clin Istanb
November 2024
Department of Pathology, Istanbul Yeni Yuzyil University, Gaziosmanpasa Hospital, Istanbul, Turkiye.
Article Synopsis
- Xanthogranulomatous inflammation is a rare and chronic inflammatory condition, and its occurrence in the appendix of children, particularly in cases of appendicitis, is extremely uncommon.
- An 8-year-old boy with Burkitt lymphoma underwent surgery for a mass in his abdomen, where doctors found that his appendix was discolored and abnormal, leading to an appendectomy.
- The pathology report confirmed xanthogranulomatous appendicitis (XGA), showing distinctive yellow coloration of the appendix and characteristic inflammatory cell infiltration, marking a unique case in medical literature.
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