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The efficacy and safety of suvemcitug, envafolimab, and FOLFIRI in microsatellite-stable or mismatch repair-proficient colorectal cancer: preliminary results of a phase 2 study.
Int J Colorectal Dis
January 2025
Internal Medicine, Jilin Cancer Hospital, Changchun, China.
Purpose: This phase II study is designed to evaluate the combination therapy involving suvemcitug and envafolimab with FOLFIRI in microsatellite-stable or mismatch repair-proficient (MSS/pMMR) colorectal cancer (CRC) in the second-line treatment setting.
Methods: This study is a non-randomized, open-label prospective study comprising multiple cohorts (NCT05148195). Here, we only report the data from the CRC cohort.
Gastric Accommodation Testing Using Hybrid Nuclear Imaging Volumetry and Combined High-Resolution Manometry-Nutrient Drink Test: A Pilot Study in Healthy Individuals.
Neurogastroenterol Motil
January 2025
Department of Nuclear Medicine, Radiotherapy & Oncology, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kota Bharu, Kelantan, Malaysia.
Background: Gastric accommodation (GA) testing is gaining clinical recognition as novel and minimally invasive modalities emerge. We investigated the feasibility of hybrid nuclear imaging volumetry (SPECT/CT) and combined high-resolution manometry-nutrient drink test (HRM-NDT) to assess GA.
Methods: In this non-randomized pilot study, [Tc]NaTcO gastric SPECT/CT (250 mL protocol) and proximal gastric HRM-NDT (~60 mL/min protocol) were performed separately within 30 days using Ensure Gold test meal (1.
Theory-driven assessment of cognitive flexibility in bulimia nervosa: a preliminary study.
Cogn Neuropsychiatry
January 2025
Department of Psychology, Ariel University, Ariel, Israel.
Background: Cognitive flexibility (CF) is defined as the ability to switch efficiently between different concepts or tasks. Empirical evidence of CF in individuals with bulimia nervosa (BN), offers conflicting conclusions, attributed to how CF is conceptualized and operationalized. The aims of the current study were to compare CF performance of women with BN to healthy controls, utilising a CF model that includes three subtypes termed: task switching, switching sets and stimulus-response mapping.
View Article and Find Full Text PDFOccipital bone modeling patterns during the first years of life: A preliminary histological and quantitative approach.
J Anat
January 2025
Laboratorio de Evolución Humana, Universidad de Burgos, Burgos, Spain.
Studies of modeling processes have provided important insights in human evolutionary discipline. Most of these studies are based on facial bones and in much lesser extent on other bones such as those from the cranial vault. Thus, this study fills a gap in research by examining occipital bone modeling in subadults, adding individuals under 2 years old and expanding the sample size available to date.
View Article and Find Full Text PDFSynthesis and antifungal activity of aldehydes-thiourea derivatives as promising antifungal agents against postharvest gray mold disease.
Chem Biodivers
January 2025
Chuxiong Normal University, Academy of Science and Technology, Chuxiong Normal University, Chuxiong, 675000，China, No. 456 Luchengnan Road, chuxiong, Academy of Science and Technology, 651000, chuxiong, CHINA.
Gray mold disease is caused by B. cinerea, which could severely reduce the production yield and quality of tomatoes. To explore more potential fungicides with new scaffolds for controlling the gray mold disease, ten aldehydes-thiourea derivatives were designed, synthesized and assayed for inhibitory activity against three plant pathogenic fungi.
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