AI Article Synopsis
- The study investigates the use of human fallopian tubes (hFTs) as a new source of multipotent stem cells, known as human tube MSCs (htMSCs), which can be obtained from discarded tissues.
- Methods used in the research included expanding hFTs, analyzing their karyotype, characterizing them through flow cytometry, and testing their ability to differentiate into various cell types like fat, cartilage, bone, and muscle.
- Results indicate that htMSCs can be easily isolated and expanded, showing potential for regenerative medicine due to their ability to differentiate into multiple cell lineages.
Article Abstract
Background: The possibility of using stem cells for regenerative medicine has opened a new field of investigation. The search for sources to obtain multipotent stem cells from discarded tissues or through non-invasive procedures is of great interest. It has been shown that mesenchymal stem cells (MSCs) obtained from umbilical cords, dental pulp and adipose tissue, which are all biological discards, are able to differentiate into muscle, fat, bone and cartilage cell lineages. The aim of this study was to isolate, expand, characterize and assess the differentiation potential of MSCs from human fallopian tubes (hFTs).
Methods: Lineages of hFTs were expanded, had their karyotype analyzed, were characterized by flow cytometry and underwent in vitro adipogenic, chondrogenic, osteogenic, and myogenic differentiation.
Results: Here we show for the first time that hFTs, which are discarded after some gynecological procedures, are a rich additional source of MSCs, which we designated as human tube MSCs (htMSCs).
Conclusion: Human tube MSCs can be easily isolated, expanded in vitro, present a mesenchymal profile and are able to differentiate into muscle, fat, cartilage and bone in vitro.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714040 | PMC |
| http://dx.doi.org/10.1186/1479-5876-7-46 | DOI Listing |
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