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Pyodermatitis vegetans confined to the umbilicus: Report of 2 cases.
Australas J Dermatol
December 2024
Department of Dermatology, Fukushima Medical University, Fukushima, Japan.
Pyodermatitis pyostomatitis vegetans is a rare variant of neutrophilic disorders, affecting the intertriginous areas such as axilla and groin, umbilicus, as well as the oral mucosa. We herein describe 2 female patients, in both of whom the umbilicus was restrictedly involved.
View Article and Find Full Text PDFDoxycycline monotherapy for pyoderma vegetans: a case report.
J Dermatolog Treat
December 2024
Department of Dermatology, Mohamed V University of Rabat, Ibn Sina University Hospital, Rabat, Morocco.
Article Synopsis
- Pyoderma vegetans (PV) is a rare skin condition characterized by neutrophilic inflammation, and its cause is not well understood.
- There are currently no official treatment guidelines for PV, with systemic steroids typically being the initial treatment option, but they often lead to recurrences when stopped.
- A study tested doxycycline at a dosage of 200 mg per day for four weeks, showing significant improvement in PV symptoms, suggesting it may be a useful alternative that reduces the reliance on systemic steroids.
Pyodermatitis-pyostomatitis vegetans: a case report and systematic review focusing on oral involvement.
Oral Maxillofac Surg
September 2024
Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Article Synopsis
- Pyodermatitis-pyostomatitis vegetans (PPV) is a rare disease indicated by pustules that often signals inflammatory bowel disease (IBD), with oral manifestations known as pyostomatitis vegetans (PSV).
- A study analyzed various cases of PSV from literature to identify key diagnostic features, including specific appearances of oral lesions and their relation to IBD.
- The research found 77 PSV cases with helpful diagnosis indicators but noted the lack of a standardized treatment approach, which typically involves multiple medications like corticosteroids and immunosuppressives, and highlighted a high risk of oral lesion recurrence upon dosage changes.
The Role of Lasers in Connective Tissue and Inflammatory Dermatoses: A 10-Year Retrospective Review of 60 Patients in a UK Tertiary Laser Clinic.
Indian Dermatol Online J
August 2023
Department of Dermatology, Laser Division, Salford Royal NHS Foundation Trust Hospital, Stott Lane, Salford, Manchester, United Kingdom.
Article Synopsis
- The study examines the effectiveness of lasers in treating inflammatory dermatoses and connective tissue disorders, noting that previous evidence on this topic is limited.
- A retrospective review of 60 cases treated at a laser clinic from 2010 to 2020 shows that 62% of patients experienced significant improvement, mainly with pulsed dye lasers, while some faced side effects like purpura.
- Despite the study's findings suggesting lasers can help manage challenging skin conditions, it acknowledges limitations due to a lack of objective measures for assessing outcomes.
Local neutrophil and eosinophil extracellular traps formation in pyodermatitis pyostomatitis vegetans.
Exp Dermatol
January 2024
Department of Dermatology, Fukushima Medical University, Fukushima, Japan.
Article Synopsis
- Pyodermatitis pyostomatitis vegetans is a rare inflammatory condition affecting the skin and/or mucous membranes, with lesions commonly appearing on the scalp, face, trunk, and extremities, as well as in oral mucosa.
- The clinical presentation includes erosive granulomatous plaques, keratotic plaques, and pustular lesions, with some lesions displaying a distinctive 'snail track' appearance.
- Unique histopathological features include epidermal hyperplasia and eosinophilic microabscesses, while activated neutrophils and eosinophil extracellular traps may play a role in its pathogenesis and inflammatory response.
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