AI Article Synopsis
- Intralesional and intra-articular corticosteroids are frequently used in dermatology, orthopedic surgery, and rheumatology for various conditions.
- A 32-year-old woman developed bilateral hypopigmented patches after receiving corticosteroids for de Quervain's tendonitis, with a later unilateral extension of these patches.
- A biopsy showed intact melanocytes, suggesting that the hypopigmentation is due to reduced melanocyte function rather than loss of the cells themselves, although the exact mechanism remains unclear.
Article Abstract
Intralesional and intra-articular corticosteroids are commonly used therapies in the fields of dermatology, orthopedic surgery and rheumatology. The authors present the case of a 32-year-old female who received intra-articular corticosteroids for de Quervain's tendonitis and developed bilateral hypopigmented patches near the areas of injection. Unilateral linear extension of the hypopigmentation was subsequently noted, presumably secondary to venous or lymphatic uptake of corticosteroid crystals. The patient complained of temperature sensitivity and increased skin fragility affecting all of the hypopigmented areas. A biopsy was performed and MART-1 immunostaining revealed intact melanocytes along the dermal-epidermal junction. The mechanism of corticosteroid-induced hypopigmentation is not well understood, but this biopsy finding supports a decrease in melanocyte function rather than actual loss of melanocytes as the cause of hypopigmentation.
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