Objective: To determine the influence of the use of central nervous system (CNS) stimulants on visual functions and occurrence of road traffic accidents (RTA) amongst commercial drivers.
Design: A cross-sectional study in which two hundred and fifteen consecutive drivers were interviewed and their eyes examined.
Settings: Ife Central Local Government Area (LGA) of Osun State, Nigeria.
Materials And Methods: Out of the estimated 270 commercial drivers registered in the four major parks of the LGA, 215 consecutive drivers participated in the survey Questionnaires were administered by face-to-face interview and the drivers' eyes examined by the authors.
Results: The prevalence of visual impairment (visual acuity < 6/18) in the better eye without correction was 3.3%, and there was a significant association between uncorrected visual acuity impairment in the better eye and RTA (p = 0.0152). The prevalence of refractive error was 8.4%, but none of these drivers wear corrective glasses. Alcohol consumption is common (57.7%) amongst the drivers, and there was a significant association between alcohol consumption and RTA (p = 0.00124). There was also a significant association between the use of CNS stimulants (kolanut, marijuana and cigarette) and RTA (p = 0.005).
Conclusion: It was therefore concluded that visual impairment in the better eye, alcohol consumption and the use of other CNS affecting substances contribute to the occurrence of RTA among the drivers.
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Adv Clin Chem
January 2025
Center for Orphan Drug Research, Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN, United States. Electronic address:
Gaucher disease (GD) is a rare lysosomal disorder characterized by the accumulation of glycosphingolipids in macrophages resulting from glucocerebrosidase (GCase) deficiency. The accumulation of toxic substrates, which causes the hallmark symptoms of GD, is dependent on the extent of enzyme dysfunction. Accordingly, three distinct subtypes have been recognized, with type 1 GD (GD1) as the common and milder form, while types 2 (GD2) and 3 (GD3) are categorized as neuronopathic and severe.
View Article and Find Full Text PDFCNS Neurosci Ther
January 2025
Department of Neurosurgery, Affiliated Qingyuan Hospital, Guangzhou Medical University, Qingyuan People's Hospital, Qiangyuan, China.
Background: During the course of the past two decades, head-mounted augmented reality surgical navigation (HMARSN) systems have been increasingly employed in a variety of surgical specialties as a result of both advancements in augmented reality-related technologies and surgeons' desires to overcome some drawbacks inherent to conventional surgical navigation systems. In the present time, most experimental HMARSN systems adopt overlain display (OD) that overlay virtual models and planned routes of surgical tools on corresponding physical tissues, organs, lesions, and so forth, in a surgical field so as to provide surgeons with an intuitive and direct view to gain better hand-eye coordination as well as avoid attention shift and loss of sight (LOS), among other benefits during procedures. Yet, its system accuracy, which is the most crucial performance indicator of any surgical navigation system, is difficult to ascertain because it is highly subjective and user-dependent.
View Article and Find Full Text PDFAnn Ital Chir
January 2025
Department of Ophthalmology, Affiliated Hospital 2 of Nantong University, 226001 Nantong, Jiangsu, China.
Aim: This study aimed to evaluate the impact of pterygium excision combined with autologous limbal stem cell transplantation on microvascular density, tear film stability, and corneal wound healing in the management of pterygium.
Methods: A retrospective analysis was conducted on 317 patients with pterygium who underwent treatment between January 2021 and January 2024. Patients were divided into a control group (pterygium excision alone, n = 161) and a study group (pterygium excision combined with autologous limbal stem cell transplantation, n = 156) based on the surgical approach.
Psychophysiology
January 2025
Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
The decline in noradrenergic (NE) locus coeruleus (LC) function in aging is thought to be implicated in episodic memory decline. Transcutaneous auricular vagus nerve stimulation (taVNS), which supports LC function, might serve to preserve or improve memory function in aging. However, taVNS effects are generally very heterogeneous, and it is currently unclear whether taVNS has an effect on memory.
View Article and Find Full Text PDFSci Rep
January 2025
Xinqiao Hospital, Army Medical University, 183th, Xinqiao Street, Shapingba District, Chongqing, China.
The purpose of this study was to evaluate the stability of small-incision lenticule extraction (SMILE) and laser in situ keratomileusis (LASIK) when ascending from near sea level to an altitude of 3874 m. The visual acuity (VA), intraocular pressure (IOP), spherical equivalent refraction (SER) and biometric parameters of 20 normal subjects (40 eyes, controls) and 36 subjects who underwent corneal refractive surgery (35 eyes with SMILE and 36 eyes with LASIK) were examined in Chongqing (C, 500 m above sea level) and 7-10 days after a collective travel to Shigatse (S, 3874 m above sea level). SER and corneal thickness (CT) were choosed as main indicators of the stability of corneal refractive surgery at high altitude.
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