AI Article Synopsis
- DNA methylation is a key epigenetic modification that regulates important cellular processes including gene expression and genomic imprinting.
- It has the potential to serve as a biomarker for identifying various tissue types and differentiation stages due to its role in phenotypic variation.
- The study finds that differences in DNA methylation within the Ddah2 gene can distinguish embryonic stem cells from neural stem cells and correlate with changes in gene expression.
Article Abstract
DNA methylation is an important epigenetic mark that is involved in the regulation of many cellular processes such as gene expression, genomic imprinting and silencing of repetitive elements. Because of their ability to cause and capture phenotypic plasticity, epigenetic marks such as DNA methylation represent potential biomarkers to distinguish between different types of tissues and stages of differentiation. Here, we have identified differential DNA methylation in the gene body of the nitric oxide inhibitor Ddah2 that discriminates embryonic stem cells from neural stem cells and is positively correlated with differential gene expression.
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| http://dx.doi.org/10.4161/epi.9093 | DOI Listing |
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