AI Article Synopsis
- ESCRT proteins are essential for endosomal trafficking and play a significant role in the formation of multivesicular bodies by helping create vesicles that bud off from the cell's cytoplasm.
- These proteins have also been found to assist in the budding process of certain retroviruses, such as HIV-1, by addressing the membranous connection between the host cell and the virus as it exits.
- Additionally, ESCRT proteins are involved in cell division, specifically during cytokinesis, by being recruited to the midbody where daughter cells separate from the mother cell.
Article Abstract
Since the initial discovery of the endosomal sorting complex required for transport (ESCRT) pathway, research in this field has exploded. ESCRT proteins are part of the endosomal trafficking system and play a crucial role in the biogenesis of multivesicular bodies by functioning in the formation of vesicles that bud away from the cytoplasm. Subsequently, a surprising role for ESCRT proteins was defined in the budding step of some enveloped retroviruses, including HIV-1. ESCRT proteins are also employed in this outward budding process, which results in the resolution of a membranous tether between the host cell and the budding virus particle. Remarkably, it has recently been described that ESCRT proteins also have a role in the topologically equivalent process of cell division. In the same way that viral particles recruit the ESCRT proteins to the site of viral budding, ESCRT proteins are also recruited to the midbody - the site of release of daughter cell from mother cell during cytokinesis. In this Commentary, we describe recent advances in the understanding of ESCRT proteins and how they act to mediate these diverse processes.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2723143 | PMC |
| http://dx.doi.org/10.1242/jcs.028308 | DOI Listing |
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