AI Article Synopsis
- TBAF-assisted N-arylation and benzylation reactions involve using benzazoles like 1H-benzimidazole and 1H-indole with aryl and benzyl halides.
- The reactions occur successfully in the presence of CuBr2 without any additional ligands, bases, or solvents.
- The process yields moderate to good results, showcasing an efficient way to modify these aromatic compounds.
Article Abstract
TBAF-assisted N-arylation and benzylation of benzazoles such as 1H-benzimidazole, 1H-indole, and 1H-benzotriazole with aryl and benzyl halides have been demonstrated under the ligand/base/solvent-free conditions. In the presence of CuBr2 and TBAF (n-Bu4NF), the azoles underwent N-arylation and benzylation with aryl and benzyl halides smoothly in moderate to good yields. It is noteworthy that the reaction is conducted under the ligand/base/solvent-free conditions.
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| http://dx.doi.org/10.1021/jo900752z | DOI Listing |
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