We report the development of a divergent synthetic process entailing four-step access to the elaborate fused skeletons reminiscent of aspidophytines and transtaganolides. A variety of branched precursors were synthesized on the basis of Ugi condensations and installation of diazoimide and subjected to rhodium-catalyzed tandem reactions. Switching of cyclization modes was demonstrated by the choice of the amine building blocks installed at site C.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/ol901020a | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Comparative Study of Trifunctionalization for Enhanced Energy and Thermal Stability in Zwitterionic Fused Triazole Skeletons.
Org Lett
January 2025
School of Materials Science & Engineering, Beijing Institute of Technology, Beijing 10081, China.
In this work, two energetic compounds 5-(3-iminio-6-nitro-3H-[1,2,4]triazolo[4,3-][1,2,4]triazol-2(7)-yl)tetrazol-1-ide () and 3-nitro-7-(2-tetrazol-5-yl)-7-[1,2,4]triazolo[4,3-][1,2,4]triazol-6-amine () were successfully synthesized from the same compound 3,6,7-triamino-7-[1,2,4]triazolo[4,3-][1,2,4]triazolium (). Both compounds contain three explosophores, amino, nitro, and tetrazole, on the fused ring. Through different functional group arrangements, possesses higher density and good thermal stability.
View Article and Find Full Text PDFMolecularly manipulating pyrazinoquinoxaline derivatives to construct NIR-II AIEgens for multimodal phototheranostics of breast cancer bone metastases.
Biomaterials
January 2025
Center for AIE Research, Guangdong Provincial Key Laboratory of New Energy Materials Service Safety, College of Materials Science and Engineering, Shenzhen University, Shenzhen, 518060, China; School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen), Guangdong, 518172, China. Electronic address:
Multimodal phototheranostics on the basis of single molecular species shows inexhaustible and vigorous vitality, particularly those emit fluorescence in the second near-infrared window (NIR-II), the construction of such exceptional molecules nonetheless retains formidably challenging. In view of the undiversified molecular skeletons and insufficient phototheranostic outputs of previously reported NIR-II fluorophores, herein, electron acceptor engineering based on heteroatom-inserted rigid-planar pyrazinoquinoxaline was manipulated to fabricate aggregation-induced emission (AIE)-featured NIR-II counterparts with donor-acceptor-donor (D-A-D) architecture. Systematical investigations substantiated that one of those synthesized AIE molecules, namely 4TPQ, incorporating a fused thiophene acceptor, synchronously exhibited high molar absorptivity (ε), NIR-II emission, typical AIE tendency, significant reactive oxygen species (ROS) generation, and high photothermal conversion efficiency.
View Article and Find Full Text PDFCurrent strategies in design and synthesis of antifungals hybrid and chimeric diazine derivatives.
Bioorg Med Chem
January 2025
Alexandru Ioan Cuza University of Iasi, Faculty of Chemistry, Bd. Carol 11, 700506 Iasi, Romania. Electronic address:
In the last decades fungal infections became a major threat to human health having an unacceptably occurrence, a high rate of mortality and the number of patients at risk for these infections continue to increase every year. An effective, modern and very useful strategy in antifungal therapy is represented by the use of chimeric and hybrid drugs, most of them being with azaheterocycle skeleton. In this review, we present an overview from the last five years of the most representative achievements in the field of chimeric and hybrid diazine derivatives with antifungal properties.
View Article and Find Full Text PDFThree new diterpenes from the roots of Salvia miltiorrhiza and their cytotoxicity.
Fitoterapia
January 2025
School of Biological Sciences and Technology, University of Jinan, Jinan 250022, China; Shandong Engineering Research Center of Key Technologies for High-Value and High-Efficiency Full Industry Chain of Lonicera japonica, Linyi 273399, China. Electronic address:
Two undescribed oxazole-containing diterpenoids (1-2) and a new diterpenoid (3) were isolated from the roots of Salvia miltiorrhiza. Their structures were elucidated by extensive HRESIMS and NMR spectroscopic analysis, and the absolute configurations of 1 and 3 were confirmed by comparison of the calculated and experimental electronic circular dichroism (ECD) spectra. Compound 1 represents the first example of an abietane diterpenoid with a benzo[d]oxazole unit fused in the ring B of the abietane skeleton.
View Article and Find Full Text PDFMandibular anatomy of a new specimen of a prozostrodontian cynodont (Eucynodontia: Probainognathia) from the Upper Triassic of Brazil.
Naturwissenschaften
January 2025
Centro de Apoio à Pesquisa Paleontológica da Quarta Colônia Universidade Federal de Santa Maria (CAPPA/UFSM, Rua Maximiliano Vizzotto, 59897230-00, São João do Polêsine, Rio Grande do Sul, Brazil.
Prozostrodontia is a clade of probainognathian cynodonts that exhibit several morphological innovations later inherited by mammals. The earliest representatives of this group have been found in the Upper Triassic deposits of southern Brazil. In this study, we report the discovery of a probainognathian cynodont from the Buriol site (São João do Polêsine, Rio Grande do Sul, Brazil), Hyperodapedon Assemblage Zone (Late Triassic).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!