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medRxiv
December 2024
Department of Biomedical Engineering, Columbia University, New York, 10027, NY, USA.
Transcranial magnetic stimulation (TMS) over the left dorsolateral prefrontal cortex (L-DLPFC) is an established intervention for treatment-resistant depression (TRD), yet the underlying therapeutic mechanisms remain not fully understood. This study employs an integrative approach that combines TMS with concurrent functional magnetic resonance imaging (fMRI) and electroencephalography (EEG), aimed at assessing the acute/immediate effects of TMS on brain network dynamics and their correlation with clinical outcomes. Our study demonstrates that TMS acutely modulates connectivity within vital brain circuits, particularly the cognitive control and default mode networks.
View Article and Find Full Text PDFNetw Neurosci
December 2024
Department of Physics, Indiana University, Bloomington, IN, USA.
Most of the recent work in psychedelic neuroscience has been done using noninvasive neuroimaging, with data recorded from the brains of adult volunteers under the influence of a variety of drugs. While these data provide holistic insights into the effects of psychedelics on whole-brain dynamics, the effects of psychedelics on the mesoscale dynamics of neuronal circuits remain much less explored. Here, we report the effects of the serotonergic psychedelic N,N-diproptyltryptamine (DPT) on information-processing dynamics in a sample of in vitro organotypic cultures of cortical tissue from postnatal rats.
View Article and Find Full Text PDFFront Neurol
December 2024
Department of Psychiatry, Shizuoka Psychiatric Medical Center, Shizuoka, Japan.
Recent studies focusing on neural activity captured by neuroimaging modalities have provided various metrics for elucidating the functional networks and dynamics of the entire brain. Functional magnetic resonance imaging (fMRI) can depict spatiotemporal functional neural networks and dynamic characteristics due to its excellent spatial resolution. However, its temporal resolution is limited.
View Article and Find Full Text PDFNeuroimage
January 2025
Meditation Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:
Using a combination of fMRI, EEG, and phenomenology ratings, we examined the neurophenomenology of advanced concentrative absorption meditation, namely jhanas (ACAM-J), in a practitioner with over 23,000 h of meditation practice. Our study shows that ACAM-J states induce reliable changes in conscious experience and that these experiences are related to neural activity. Using resting-state fMRI functional connectivity, we found that ACAM-J is associated with decreased within-network modularity, increased global functional connectivity (GFC), and desegregation of the default mode and visual networks.
View Article and Find Full Text PDFCognition
January 2025
Department of Neuroscience, University of Florence, Italy.
Adaptation is a ubiquitous property of perceptual systems, increasing sensitivity to change and allowing them to operate over a large dynamic range. The number sense, like most other perceptual systems, is adaptable. Yousif et al.
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