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Geometry of a weight-bearing and non-weight-bearing bone in the legs of young, old, and very old men. | LitMetric

Geometry of a weight-bearing and non-weight-bearing bone in the legs of young, old, and very old men.

Calcif Tissue Int

Canadian Centre for Activity and Aging, School of Kinesiology, The University of Western Ontario, Arthur and Sonia Labatt Health Sciences Building, London, ON N6A 5B9, Canada.

Published: July 2009

Bone geometry is an important determinant of bone strength and is influenced by muscle pull and weight-bearing. Muscle mass and exposure to weight-bearing decrease with age and thus the purpose of the study was to compare bone geometry of the weight-bearing (tibia) and non-weight-bearing (fibula) bones of the leg in different age groups. Magnetic resonance images of the right leg were acquired in 13 young (26 yr), 13 old (66 yr), and 13 very old men (83 yr). Cortical, medullary and total cross-sectional areas (CSA) of the bones were measured at approximately one-third and two-thirds the length of the leg. Muscle CSA of the anterior, lateral and posterior compartments was measured at the proximal site. Cortical CSA was approximately 14 to 22% smaller in the elderly in the tibia but similar across age in the fibula. Medullary CSA was larger with age (approximately 5 to 65%) in both bones but approximately 15 to 440% greater in the tibia than fibula. Total CSA was similar across age in both bones. Muscle mass was similar between young and old but approximately 25% less in the very old and as a consequence, the magnitude of differences in bone geometry at proximal and distal sites varied in the two elderly groups. These findings indicate that there is a complex age-dependent interaction between muscle pull and weight-bearing. The greater age-related differences in bone geometry in the tibia suggest the weight-bearing role of the tibia makes it more susceptible than the fibula to the reduced activity typically associated with aging.

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Source
http://dx.doi.org/10.1007/s00223-009-9261-7DOI Listing

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