The ionic liquids N-methylpyridinium-2-carboxaldehyde Tf(2)N(-) and N-methylpyridinium-3-carboxaldehyde Tf(2)N(-) form readily-reversible covalent bonds with protic nucleophiles, creating all-liquid constitutionally dynamic materials.
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http://dx.doi.org/10.1039/b901899a | DOI Listing |
Chin Med
January 2025
School of Pharmacy, Hangzhou Normal University, Hangzhou, China.
Background: The individualized prediction and discrimination of precancerous lesions of gastric cancer (PLGC) is critical for the early prevention of gastric cancer (GC). However, accurate non-invasive methods for distinguishing between PLGC and GC are currently lacking. This study therefore aimed to develop a risk prediction model by machine learning and deep learning techniques to aid the early diagnosis of GC.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
January 2025
The Hebrew University of Jerusalem - Givat Ram Campus: Hebrew University of Jerusalem - Edmond J Safra Campus, Institute of Chemistry, Givat Ram, 91904, Jerusalem, ISRAEL.
A method to photomodulate dynamically transient DNA-based reaction circuits and networks is introduced. The method relies on the integration of photoresponsive o-nitrobenzyl-phosphate ester-caged DNA hairpin with a "mute" reaction module. Photodeprotection (λ = 365 nm) of the hairpin structure separates a fuel strand triggering the dynamic, transient, operation of the DNA circuit/network.
View Article and Find Full Text PDFInt J Biol Sci
January 2025
School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China.
Front Pharmacol
December 2024
Department of oncology, The Third Affiliated Hospital, Beijing University of Chinese Medicine, Beijing, China.
Introduction: The Xihuang Pill (XHP), a venerated traditional Chinese medicine, has demonstrated significant anti-cancer capabilities. Despite its proven efficacy, the scarcity of comprehensive pharmacological studies limits the widespread application of XHP. This research endeavor seeks to demystify the therapeutic underpinnings of XHP, particularly in the realm of colorectal cancer (CRC) therapy.
View Article and Find Full Text PDFDrug Des Devel Ther
December 2024
School of Basic Medical Sciences, Shaanxi University of Chinese Medicine, Xianyang, People's Republic of China.
Background: Precancerous lesions of gastric cancer (PLGC) represent critical stages in gastric cancer progression, with a high risk of malignancy. Current treatments, such as Helicobacter pylori eradication, show limited efficacy in reversing precancerous molecular changes. Zuojin Pill (ZJP), a traditional Chinese medicine, has demonstrated potential for treating digestive disorders and may offer a promising approach for PLGC intervention.
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