The data on the effect of a peptide from the squid optic ganglia named gangliin on some parameters of animal natural resistance are presented. It was shown that the prophylactic use of the peptide in mice 24 hours before their contamination with the lethal dose of E. coli protected 40 to 60 per cent of the animals from death. Gangliin accelerated elimination of E. coli from the host and increased the absorptive and digestive activity of the macrophages and polymorphonuclear leukocytes. With the use of gangliin it was possible to correct the phagocytosis defects in infectious processes having the phagocytic protection mechanism. Moreover, gangliin was supposed to be efficient in control of long-term persistence of various microbes in the cells of the system of mononuclear phagocytes.
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[Effect of electroacupuncture on blood-brain barrier and central inflammatory response in obese rats].
Zhen Ci Yan Jiu
December 2024
College of Acupuncture-moxibustion and Orthopedics-traumatology, Hubei University of Chinese Medicine, Wuhan 430060, China.
Article Synopsis
- The study aimed to investigate how electroacupuncture (EA) impacts the inflammatory response in the brains of obese rats, potentially revealing mechanisms for obesity improvement.
- Male SD rats were divided into four groups (normal control, model, EA, sham-EA) and subjected to an 8-week high-fat diet to induce obesity; EA was applied to specific acupoints to measure various health indicators.
- Results showed significant increases in body mass, inflammatory markers, and hypothalamic protein levels in the obesity model group, but also some elevated levels of anti-inflammatory markers following EA, indicating a potential therapeutic effect.
Molecular hybridization modification improves the stability and immunomodulatory activity of TP5 peptide.
Front Immunol
November 2024
State Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing, China.
Thymopentin (TP5) plays an important role in host immunomodulation, yet its bioavailability is significantly limited by its short half-life. YW12D is a peptide with strong stability but relatively weak immunoactivity. Tuning the physicochemical properties of such molecules may yield synthetic molecules displaying optimal stability, safety and enhanced immunological activity.
View Article and Find Full Text PDF[Effects of electroacupuncture on expression of miR-218 and HMGB1/TLR4 signaling pathway in rats with focal cerebral ischemia].
Zhen Ci Yan Jiu
November 2024
College of Acupuncture-Moxibustion and Tuina, Anhui University of Chinese Medicine, Hefei 230012.
Objectives: To observe the effect of electroacupuncture (EA) on high mobility group box 1 (HMGB1) / toll-like receptor 4 (TLR4) signaling pathway and inflammatory injury in rats with focal cerebral ischemia (FCI), so as to explore its mechanisms underlying amelioration of ischemic stroke.
Methods: Male SD rats were randomly divided into sham operation (=18), model (=18) and EA (=18) groups. The FCI model was established according to Longa's method.
[Effect of electroacupuncture at "Baihui" (GV20) and "Zusanli" (ST36) on angiogenesis in the brain of middle cerebral artery occlusion rats based on HIF/VEGF/Notch signaling pathway].
Zhen Ci Yan Jiu
October 2024
The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000.
Article Synopsis
- - The study aimed to investigate how electroacupuncture (EA) affects the HIF/VEGF/Notch signaling pathways in rats with cerebral ischemia, focusing on its potential role in enhancing cerebral microangiogenesis and improving brain function.
- - It included 100 male SD rats, with 15 in a sham group and the remaining 85 subjected to a cerebral ischemia model; various therapies, including EA and specific inhibitors, were administered to study their effects on neurological deficits and brain tissue characteristics.
- - Results showed significant differences in neurological scores, cerebral infarct volume, microvascular density, and the expression of key proteins related to the signaling pathways in rats treated with EA compared to controls, highlighting the beneficial effects of EA
Objectives: To observe the effects of electroacupuncture (EA) stimulation of "Sishencong"(EX-HN1) and "Fengchi"(GB20) on lactate (Lac) content, expression of proline hydroxylase 2 (PHD2), hypoxia-inducible factor-1α (HIF-1α)/nuclear transcription factor- κB (NF- κB)/NOD-like receptor thermoprotein structural domain-associated protein 3 (NLRP3) signaling pathway, and inflammatory factors in hippocampal tissue of vascular dementia (VD) rats, so as to explore its mechanisms underlying improvement of VD.
Methods: Male SD rats screened by Morris water maze tests were randomly divided into blank control, sham-operation, VD model and EA groups (12 rats in each group). The VD model was replicated using the 4-vessel occlusion (VO) method.
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