Cell polarity is crucial for the generation of cell diversity. Recent evidence suggests that the actin cytoskeleton plays a key role in establishment of embryonic polarity, yet the mechanisms that maintain polarity cues in particular membrane domains during development remain unclear. Dynamin, a large GTPase, functions in both endocytosis and actin dynamics. Here, the Caenorhabditis elegans dynamin ortholog, DYN-1, maintains anterior polarity cues. DYN-1-GFP foci are enriched in the anterior cortex in a manner dependent on the anterior polarity proteins, PAR-6 and PKC-3. Membrane internalization and actin comet formation are enriched in the anterior, and are dependent on DYN-1. PAR-6-labeled puncta are also internalized from cortical accumulations of DYN-1-GFP. Our results demonstrate a mechanism for the spatial and temporal regulation of endocytosis in the anterior of the embryo, contributing to the precise localization and maintenance of polarity factors within a dynamic plasma membrane.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719978 | PMC |
| http://dx.doi.org/10.1016/j.devcel.2009.04.009 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Rectification of planar orientation angle switches behavior and replenishes contractile junctions.
J Cell Biol
April 2025
Department of Physics and Astronomy, University of Denver, Denver, CO, USA.
In the early Drosophila embryo, germband elongation is driven by oriented cell intercalation through t1 transitions, where vertical (dorsal-ventral aligned) interfaces contract and then resolve into new horizontal (anterior-posterior aligned) interfaces. Here, we show that contractile events produce a continuous "rectification" of cell interfaces, in which interfaces systematically rotate toward more vertical orientations. As interfaces rotate, their behavior transitions from elongating to contractile regimes, indicating that the planar polarized identities of cell-cell interfaces are continuously re-interpreted in time depending on their orientation angle.
View Article and Find Full Text PDFPolydatin retards the progression of osteoarthritis by maintaining bone metabolicbalance and inhibiting macrophage polarization.
Front Bioeng Biotechnol
January 2025
The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Background: Polydatin (PD), also known as tiger cane glycoside, is a natural compound extracted from the Japanese knotweed plant, which is often referred to as white resveratrol. It exhibits anti-inflammatory, antioxidant, and anti-apoptotic effects in the treatment of various diseases. However, the potential molecular mechanisms of PD in osteoarthritis have not been clearly elucidated.
View Article and Find Full Text PDFWe describe and characterize a new species from the Singing honeyeater () in Western Australia, both morphologically and molecularly. Microscopic analysis of a fecal sample identified 25 ellipsoidal oocysts, measuring 21-25 × 18-20 μm (mean 23.4 × 18.
View Article and Find Full Text PDFMorphology and Phylogenetic Analysis of Henneguya sp. Infecting the Orange-Spotted Snakehead (Channa Aurantimaculata) from Tamil Nadu, India.
Acta Parasitol
January 2025
ICAR-Central Island Agricultural Research Institute, Andaman & Nicobar Islands, Port Blair, India.
Purpose: Henneguya sp. is a crucial myxosporean parasite known to cause milky flesh or tapioca disease in the freshwater fish population, leading to heavy mortality. Studies to investigate its host range and to monitor their prevalence in wild and aquacultured fish are necessary.
View Article and Find Full Text PDFConstruction and application of a three-dimensional vascular variation-based nephrometry scoring system for completely endophytic renal tumors.
J Natl Cancer Cent
December 2024
Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China.
Article Synopsis
- Completely endophytic renal tumors (CERT) complicate surgical procedures due to their hidden locations, prompting the need for a 3D scoring model (RAL) based on imaging to improve assessment and outcomes.
- In a study of 80 patients, those evaluated with 3D images (3D-Cohort) experienced fewer complications and better kidney function outcomes than those assessed with traditional 2D images (2D-Cohort), who faced longer surgeries and more significant bleeding.
- The RAL scoring system was found to effectively predict surgical challenges and kidney function decline, with higher scores indicating larger tumors and greater operational issues.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!