Light profile microscopy (LPM) is a direct method for the spectral depth imaging of thin film cross-sections on the micrometer scale. LPM uses a perpendicular viewing configuration that directly images a source beam propagated through a thin film. Images are formed in dark field contrast, which is highly sensitive to subtle interfacial structures that are invisible to reference methods. The independent focusing of illumination and imaging systems allows multiple registered optical sources to be hosted on a single platform. These features make LPM a powerful multi-contrast (MC) imaging technique, demonstrated in this work with six modes of imaging in a single instrument, based on (1) broad-band elastic scatter; (2) laser excited wideband luminescence; (3) coherent elastic scatter; (4) Raman scatter (three channels with RGB illumination); (5) wavelength resolved luminescence; and (6) spectral broadband scatter, resolved in immediate succession. MC-LPM integrates Raman images with a wider optical and morphological picture of the sample than prior art microprobes. Currently, MC-LPM resolves images at an effective spectral resolution better than 9 cm(-1), at a spatial resolution approaching 1 microm, with optics that operate in air at half the maximum numerical aperture of the prior art microprobes.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1366/000370209788559638 | DOI Listing |
Curr Dev Nutr
January 2025
School of Food Science and Nutrition, University of Leeds, Leeds, West Yorkshire, United Kingdom.
Background: Regulations restricting the promotion of some less-healthy products high in fat, sugar, or salt (HFSS) within "restricted areas" (RAs) of supermarkets came into force in October 2022 in England.
Objectives: To evaluate the prevalence of HFSS products and front-of-pack nutrition labeling (FOPNL) characteristics of foods sold within RAs in a sample of supermarket stores.
Methods: A cross-sectional survey of products in RAs in 3 supermarkets was undertaken from November 2022 to February 2023 using photographs, recording the display of FOPNL.
Med J Armed Forces India
December 2024
Professor (Lab Sciences & Molecular Medicine), Army Hospital (R&R), Delhi Cantt, India.
Background: Plasma cell myeloma (PCM) is a common adult hematological neoplasm of terminally differentiated B-cells resulting in accumulation of monoclonal plasma cells. PCM is heterogeneous disease with survival time varies from months to years, determined by age, stage, cytogenetics abnormalities, and treatment response. There is conflicting evidence in role of immunophenotype as a prognostic indicator.
View Article and Find Full Text PDFEnviron Pollut
December 2024
Department of Epidemiology and Health Statistics, School of Public Health, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, China; Key Laboratory of Environmental Factors and Chronic Disease Control, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, China. Electronic address:
Current literature lacks information regarding impacts of green spaces on susceptibility to cardiovascular disease (CVD) related to harmful environmental exposures. The UK Biobank cohort study was utilized to investigate whether green spaces can mitigate risks associated with air pollutants, nighttime light, noise, and traffic intensity. Latent Profile Analysis was performed on green spaces and adverse environmental exposures in order to assess individual level exposure.
View Article and Find Full Text PDFInt J Biol Macromol
December 2024
Wuya College of Innovation, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang 110016, China. Electronic address:
Oxidative stress results from an imbalance between the production of free radicals by oxidants and their removal by antioxidants. Chronic oxidative stress is a key factor in inflammation, characterized by hypoxic microenvironments and elevated levels of reactive oxygen species (ROS). Psoriasis, a common chronic inflammatory skin disorder, profoundly impacts the physical and psychological well-being of affected individuals.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
Introduction: Type 2 diabetes increases the risk of Alzheimer's disease (AD) dementia. Insulin signaling dysfunction exacerbates tau protein phosphorylation, a hallmark of AD pathology. However, the comprehensive impact of diabetes on patterns of AD-related phosphoprotein in the human brain remains underexplored.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!