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A 5-year Single-center Experience on the Use of Emicizumab Prophylaxis in Children With Severe Hemophilia A With and Without Factor VIII Inhibitors.
J Pediatr Hematol Oncol
January 2025
Department of Paediatric Haematology, NHS Foundation Trust, Birmingham Children's Hospital, Birmingham, UK.
Objective: Emicizumab promotes efficacious hemostasis in persons with hemophilia A persons with hemophilia A with and without inhibitors. Primary analyses of real-world data and clinical trials have shown emicizumab efficacy and safety; however, long-term data are limited.
Methods: This retrospective study was conducted to assess real-world long-term outcomes of pediatric patients on emicizumab in our hemophilia center between the period of February 2018 and September 2023.
Clinical outcomes of conversion prosthesis in immediately loaded implants: A retrospective study.
J Prosthodont
January 2025
Department of Community Medicine and Health Care, University of Connecticut Health Center, Farmington, Connecticut, USA.
Purpose: The primary objective of this retrospective study was to evaluate the survival outcomes of immediately loaded acrylic resin complete arch fixed implant-supported prosthesis (CAFIP) fabricated from the denture conversion protocol. The secondary objective was to evaluate the early implant survival outcomes associated with these prostheses.
Material And Methods: A retrospective chart review was conducted to study the clinical outcomes data of immediately loaded conversion prostheses and immediately loaded implants.
Experimental study on the preventive effect of Anemarrhena rhizome on pregnancy loss and the incidence rate of cleft palate in A/J mice.
Congenit Anom (Kyoto)
January 2025
Division of Research and Treatment for Oral and Maxillofacial Congenital Anomalies, School of Dentistry, Aichi Gakuin University, Nagoya, Japan.
Pregnancy loss is a significant concern worldwide, encompassing miscarriage and stillbirth. Miscarriage, defined as the loss of a baby before 28 weeks of gestation, accounts for approximately 15% of pregnancies. Stillbirth, occurring at or after 28 weeks of gestation, affects nearly 2.
View Article and Find Full Text PDFEmpagliflozin in diabetic cardiomyopathy: elucidating mechanisms, therapeutic potentials, and future directions.
Mol Biol Rep
January 2025
Department of Pharmacology, Central University of Punjab, Bathinda, Punjab, 151401, India.
Diabetic cardiomyopathy (DCM) represents a significant health burden, exacerbated by the global increase in type 2 diabetes mellitus (T2DM). This condition contributes substantially to the morbidity and mortality associated with diabetes, primarily through myocardial dysfunction independent of coronary artery disease. Current treatment strategies focus on managing symptoms rather than targeting the underlying pathophysiological mechanisms, highlighting a critical need for specific therapeutic interventions.
View Article and Find Full Text PDFCoronectomy of mandibular third molars with dental pathology: a prospective cohort study of 121 molars.
Oral Maxillofac Surg
January 2025
Department of Oral and Maxillofacial Surgery, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Purpose: Coronectomy is a valuable treatment proven safe for non-pathological mandibular third molars with an increased risk of inferior alveolar nerve injury. Coronectomy may also be useful for mandibular third molars with dentigerous cysts and caries, but this is not commonly performed due to the lack of well-designed, evidence-based studies. Here, we aim to investigate the safety of coronectomy for mandibular third molars with caries and dentigerous cysts.
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