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Malignant behaviors and immune response in melanoma: Epstein-Barr virus induced gene 3 as a therapeutic target based on an exploration.
PeerJ
December 2024
Department of Medical Aesthetics, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Background: Epstein-Barr virus induced gene 3 (), a member of the IL-12 family, is known to be involved in malignant progression in a variety of cancers, but its role in melanoma is unclear. The aim of this study was to explore the effects of EBI3 on the malignant phenotype melanoma to reveal its potential as a therapeutic target.
Methods: In this study, we used bioinformatics to analyze the expression of in pan-cancer and verified its expression level in melanoma cells by reverse transcription-quantitative polymerase chain reaction (RT-qPCR).
Beyond IL-35 and IL-27: Epstein-Barr Virus-induced Gene 3 as a Novel Mediator of T Cell Exhaustion in Gastric Cancer.
J Am Coll Surg
December 2024
Shanghai, China.
Precision meets repurposing: Innovative approaches in human papillomavirus and Epstein-Barr virus-driven cancer therapy.
Cancer Lett
December 2024
Translational Cancer Research Facility, National Centre for Cancer Care and Research, Hamad Medical Corporation P.O. Box 3050, Doha, Qatar; College of Medicine, Qatar University, P.O. Box 2713, Doha, Qatar. Electronic address:
Viral malignancies represent a distinct entity among cancers. Oncoviruses like the Human Papilloma Virus (HPV) and the Epstein Barr Virus (EBV) are highly potent inducers of oncogenic transformation leading to tumor development. HPV and EBV are known to be increasingly involved in the pathogenesis of various classes of cancers like cervical, head and neck, colorectal, breast, oral and anogenitial.
View Article and Find Full Text PDFIs There such a Thing as Post-Viral Depression?: Implications for Precision Medicine.
Biomol Ther (Seoul)
November 2024
Department of Psychiatry, Korea University Anam Hospital, Korea University College of Medicine, Seoul 02841, Republic of Korea.
Article Synopsis
- Viral infections, especially after the COVID-19 pandemic, are linked to depressive disorders, with specific viruses like HSV, EBV, CMV, and HIV involved through complex mechanisms.
- These mechanisms include immune system dysregulation, chronic inflammation, and neurotransmitter imbalances that affect brain function and mood.
- The review highlights the importance of developing virus-specific treatments, such as immunomodulatory and antiviral therapies, to better address the unique neurobiological effects of different viruses on depression.
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