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Multi-omics analyses of early-onset familial Alzheimer's disease and Sanfilippo syndrome zebrafish models reveal commonalities in disease mechanisms.
Biochim Biophys Acta Mol Basis Dis
January 2025
Alzheimer's Disease Genetics Laboratory, School of Molecular and Biomedical Sciences, Faculty of Sciences, Engineering and Technology, The University of Adelaide, North Terrace Campus, Adelaide, SA 5005, Australia.
Sanfilippo syndrome (mucopolysaccharidosis type III, MPSIII) causes childhood dementia, while Alzheimer's disease is the most common type of adult-onset dementia. There is no cure for either of these diseases, and therapeutic options are extremely limited. Increasing evidence suggests commonalities in the pathogenesis of these diseases.
View Article and Find Full Text PDFA Novel Liquid Chromatography-Tandem Mass Spectrometry Method to Quantify Tryptophan and Its Major Metabolites in Serum to Support Biomarker Studies in Patients with Cancer Undergoing Immunotherapy.
Molecules
December 2024
Department of Physical Pharmacy and Pharmacokinetics, Poznan University of Medical Sciences, 3 Rokietnicka Street, 60-806 Poznań, Poland.
Tryptophan (TRP) is an essential amino acid crucial for the production of many bioactive compounds. Disturbances in TRP metabolism have been revealed in various diseases, many of which are closely related to the immune system. In recent years, we have focused on finding blood-based biomarkers of successful immunotherapy in cancer.
View Article and Find Full Text PDFParaplegia Caused by a Large Spinal Epidural Hematoma 12 Days After Thoracic Decompression and Fusion.
Cureus
December 2024
Orthopaedic Surgery, Kyushu Central Hospital of the Mutual Aid Association of Public School Teachers, Fukuoka, JPN.
A 41-year-old man with a history of obesity, hypertension, and smoking suffered from numbness and weakness in both lower limbs. He was diagnosed with ossification of the posterior longitudinal ligament and ligamentum flavum in the cervical and thoracic spine by X-rays, CT, and MRI. The patient underwent laminectomies at T2 and T3 levels, along with posterior fusion from T1 to T4, to address an upper thoracic spine lesion causing sensory deficits up to T5 and gait disturbances.
View Article and Find Full Text PDFTargeted screening, characterization and sources of per- and polyfluoroalkyl substances in plateau lake Yangzonghai, China.
Environ Geochem Health
December 2024
College of Resources and Environment, Chengdu University of Information Technology, Chengdu, 610025, China.
Per- and polyfluoroalkyl substances (PFAS) have been detected in lake ecosystems globally, even in remote areas at high altitudes. Compared to plain lakes with short water change cycles and significant human influence, plateau lakes are primarily tectonic closed or semi-closed lakes with steep terrain. Their long water change cycles lead to an obvious cumulative effect on pollutants.
View Article and Find Full Text PDFConcept and framework of digital twin human geographical environment.
J Environ Manage
January 2025
School of Geography and Environment & Key Laboratory of Poyang Lake Wetland and Watershed Research, Ministry of Education, Jiangxi Normal University, Nanchang, 330022, China. Electronic address:
The human geographical environment is a comprehensive setting formed by the interaction between human activities and the geographical environment, characterized by its complexity and vulnerability. Applying the digital twin method to create a new research model in a human geographical environment holds significant academic and practical value. This approach helps avoid disturbances in the real environment, deeply explores complex issues, and optimizes solutions for real-world geographical problems.
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